An Organ‐on‐Chip Platform for Simulating Drug Metabolism Along the Gut–Liver Axis (Adv. Healthcare Mater. 20/2024)
Sign Up to like & getrecommendations! Published in 2024 at "Advanced Healthcare Materials"
DOI: 10.1002/adhm.202470129
Abstract: introduce an integrated multiorgan-on-a-chip platform combining the HuMiX gut-on-chip and Dynamic42 liver-on-chip to mimic the gut-liver axis. This system supports intestinal and liver cell functionality, and in a proof-of-concept study, successfully recapitulates irinotecan metabolism. It… read more here.
Keywords: gut liver; drug; metabolism; chip ... See more keywords
A microfabricated nerve-on-a-chip platform for rapid assessment of neural conduction in explanted peripheral nerve fibers
Sign Up to like & getrecommendations! Published in 2018 at "Nature Communications"
DOI: 10.1038/s41467-018-06895-7
Abstract: Peripheral nerves are anisotropic and heterogeneous neural tissues. Their complex physiology restricts realistic in vitro models, and high resolution and selective probing of axonal activity. Here, we present a nerve-on-a-chip platform that enables rapid extracellular… read more here.
Keywords: nerve; nerve chip; chip platform; physiology ... See more keywords
A high-throughput gut-on-chip platform to study the epithelial responses to enterotoxins
Sign Up to like & getrecommendations! Published in 2024 at "Scientific Reports"
DOI: 10.1038/s41598-024-56520-5
Abstract: Enterotoxins are a type of toxins that primarily affect the intestines. Understanding their harmful effects is essential for food safety and medical research. Current methods lack high-throughput, robust, and translatable models capable of characterizing toxin-specific… read more here.
Keywords: high throughput; study; throughput gut; chip platform ... See more keywords
Ultrasound-on-chip platform for medical imaging, analysis, and collective intelligence
Sign Up to like & getrecommendations! Published in 2021 at "Proceedings of the National Academy of Sciences of the United States of America"
DOI: 10.1073/pnas.2019339118
Abstract: Significance Affordable hand-held ultrasound is transforming health care as a diagnostic tool with the potential to be as ubiquitous as the stethoscope. Here, we present a platform for advancing diagnostic care consisting of an ultrasound-on-chip… read more here.
Keywords: intelligence; chip platform; platform medical; ultrasound chip ... See more keywords
Cellular considerations for optimizing bone cell culture and remodeling in a lab-on-a-chip platform.
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DOI: 10.2144/btn-2019-0115
Abstract: Our lab has developed a lab-on-a-chip platform for bone remodeling that enables long-term culturing of bone cells out to 7 weeks and serves as a foundation toward a multicellular organ-on-a-chip system. Here, we optimized culturing protocols… read more here.
Keywords: chip platform; bone; culture; chip ... See more keywords
Human Multi-Compartment Airways-on-Chip Platform for Emulating Respiratory Airborne Transmission: From Nose to Pulmonary Acini
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Physiology"
DOI: 10.3389/fphys.2022.853317
Abstract: The past decade has witnessed tremendous endeavors to deliver novel preclinical in vitro lung models for pulmonary research endpoints, including foremost with the advent of organ- and lung-on-chips. With growing interest in aerosol transmission and… read more here.
Keywords: platform; chip platform; transmission; physiology ... See more keywords