iPSCs-laden GDF8-grafted aldehyde hyaluronic acid-polyacrylamide inverted colloidal crystal constructs with controlled release of CHIR99021 and retinoic acid to generate insulin-producing cells
Sign Up to like & getrecommendations! Published in 2020 at "Journal of The Taiwan Institute of Chemical Engineers"
DOI: 10.1016/j.jtice.2020.11.002
Abstract: Abstract Recent advances in attempting maturation of pancreatic β cells derived from induced pluripotent stem cells (iPSCs) have initiated a gateway to developing innovated materials and protocols for artificial pancreas implantation in diabetic management. In… read more here.
Keywords: producing cells; chir99021; colloidal crystal; inverted colloidal ... See more keywords
Small Molecule GSK-3 Inhibitors Safely Promote the Proliferation and Viability of Human Dental Pulp Stem Cells—In Vitro
Sign Up to like & getrecommendations! Published in 2023 at "Biomedicines"
DOI: 10.3390/biomedicines11020542
Abstract: Small molecules have demonstrated promising results as successful alternatives to growth factors. In this study, focus was drawn to CHIR99021 and tideglusib as GSK-3 inhibitors known for their anti-inflammatory and regenerative potential. The effect of… read more here.
Keywords: proliferation viability; gsk inhibitors; proliferation; tideglusib ... See more keywords
Combination of SB431542, CHIR99021 and PD0325901 has a synergic effect on abrogating valproic acid‑induced epithelial‑mesenchymal transition and stemness in HeLa, 5637 and SCC‑15 cells.
Sign Up to like & getrecommendations! Published in 2019 at "Oncology reports"
DOI: 10.3892/or.2019.7088
Abstract: Epithelial‑mesenchymal transition (EMT) plays an important role in cancer progression, metastasis and drug resistance, and recent studies have revealed that neoplastic epithelial cells regain the stem cell state through EMT. Single‑agent targeted cancer therapy frequently… read more here.
Keywords: mesenchymal transition; chir99021; epithelial mesenchymal; cancer cells ... See more keywords