DFT Mechanism Studies: Biomimetic 1,4-NADH Chemoselective, Co-factor Regeneration with [Cp*Rh(bpy)H]+, in Tandem with the Biocatalysis Pathways of a Core Model of the (HLADH)-Zn(II) Mediated Enzyme, in the Enantioselective Reduction of Achiral Ketones to Chiral S-Alcohols
Sign Up to like & getrecommendations! Published in 2021 at "Journal of Organometallic Chemistry"
DOI: 10.1016/j.jorganchem.2021.121810
Abstract: Abstract Quantum Chemical (QC) calculations, utilizing Density Functional Theory (DFT), were performed to investigate the mechanistic aspects of the chemoselective catalyzed reaction of [Cp*Rh(bpy)H]+ with the biomimetic NAD+ analogues, N-benzylnicotinamide triflate, 1, and β-nicotinamide ribose-5′-methyl… read more here.
Keywords: reduction achiral; chiral alcohols; hladh; factor ... See more keywords
Significantly enhancing the biocatalytic synthesis of chiral alcohols by semi-rationally engineering an anti-Prelog carbonyl reductase from Acetobacter sp. CCTCC M209061
Sign Up to like & getrecommendations! Published in 2019 at "Molecular Catalysis"
DOI: 10.1016/j.mcat.2019.110613
Abstract: Abstract Chiral alcohols and their derivatives are vital building blocks to synthesize pharmaceutical drugs and high-valued chemicals. Wild-type carbonyl reductase AcCR from Acetobacter sp. has ideal enantioselectivity toward 11 prochiral substrates (e.e.>99%) but poor activity.… read more here.
Keywords: synthesis chiral; acetobacter; carbonyl reductase; chiral alcohols ... See more keywords
Preparation of Structurally Diverse Chiral Alcohols by Engineering Ketoreductase CgKR1
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DOI: 10.1021/acscatal.7b01933
Abstract: Ketoreductases are tools for the synthesis of chiral alcohols in industry. However, the low activity of natural enzymes often restricts their use in industrial applications. On the basis of computational analysis and previous reports, two… read more here.
Keywords: structurally diverse; chiral alcohols; ketoreductase cgkr1; activity ... See more keywords
Engineering ketoreductases for the enantioselective synthesis of chiral alcohols.
Sign Up to like & getrecommendations! Published in 2023 at "Chemical communications"
DOI: 10.1039/d3cc01474f
Abstract: The use of engineered ketoreductases (KREDS), both as whole microbial cells and isolated enzymes, in the highly enantiospecific reduction of prochiral ketones is reviewed. The homochiral alcohol products are key intermediates in, for example, pharmaceuticals… read more here.
Keywords: engineering ketoreductases; enantioselective synthesis; ketoreductases enantioselective; chiral alcohols ... See more keywords
Ketoreductase Catalyzed (Dynamic) Kinetic Resolution for Biomanufacturing of Chiral Chemicals
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Bioengineering and Biotechnology"
DOI: 10.3389/fbioe.2022.929784
Abstract: Biocatalyzed asymmetric reduction of ketones is an environmentally friendly approach and one of the most cost-effective routes for producing chiral alcohols. In comparison with the well-studied reduction of prochiral ketones to generate chiral alcohols with… read more here.
Keywords: chiral alcohols; biomanufacturing chiral; resolution; chiral chemicals ... See more keywords