Sequence‐Guided Redesign of an Omega‐Transaminase from Bacillus megaterium for the Asymmetric Synthesis of Chiral Amines
Sign Up to like & getrecommendations! Published in 2024 at "ChemBioChem"
DOI: 10.1002/cbic.202400285
Abstract: ω‐Transaminases (ω‐TAs) are attractive biocatalysts asymmetrically catalyzing ketones to chiral amines. However, poor non‐native catalytic activity and substrate promiscuity severely hamper its wide application in industrial production. Protein engineering efforts have generally focused on reshaping… read more here.
Keywords: sequence; chiral amines; bacillus megaterium; activity ... See more keywords
Construction of Multi‐Enzyme Integrated Catalysts for Deracemization of Cyclic Chiral Amines
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DOI: 10.1002/cbic.202400346
Abstract: Multi‐enzyme cascade catalysis has become an important technique for chemical reactions used in manufacturing and scientific study. In this research, we designed a four‐enzyme integrated catalyst and used it to catalyse the deracemization reaction of… read more here.
Keywords: chiral amines; multi enzyme; cyclic chiral; enzyme ... See more keywords
Catalytic Enantioconvergent C(sp3)−N Coupling to Access Chiral Amines: A Concept Review
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DOI: 10.1002/cctc.202400049
Abstract: Nitrogen containing compounds like chiral amines have been widely used in synthetic medicines, biomass, and fine chemical products because of their particularly valuable motifs and exceedingly broad range of functionality. Enantioconvergent synthesis of chiral amines… read more here.
Keywords: catalytic enantioconvergent; chiral amines; sp3 coupling; enantioconvergent sp3 ... See more keywords
Enantioseparation and molecular modeling study of chiral amines as three naphthaldimine derivatives using amylose or cellulose trisphenylcarbamate chiral stationary phases.
Sign Up to like & getrecommendations! Published in 2022 at "Chirality"
DOI: 10.1002/chir.23513
Abstract: This study describes the enantioseparation of three chiral amines as naphthaldimine derivatives, using normal phase HPLC with amylose and cellulose tris(3,5-dimethylphenylcarbamate) chiral stationary phases (CSPs). Three chiral amines were derivatized using three structurally similar naphthaldehyde… read more here.
Keywords: naphthaldimine derivatives; stationary phases; chiral amines; derivatives using ... See more keywords
In situ removal of inhibitory products with ion exchange resins for enhanced synthesis of chiral amines using ω-transaminase
Sign Up to like & getrecommendations! Published in 2020 at "Biochemical Engineering Journal"
DOI: 10.1016/j.bej.2020.107718
Abstract: Abstract ω-Transaminase (ω-TA) serves as an attractive biocatalyst for the asymmetric synthesis of chiral amines from prochiral ketones. However, the ω-TA reactions suffer from exceedingly unfavorable equilibrium and severe product inhibitions. Most reaction engineering strategies… read more here.
Keywords: synthesis chiral; removal inhibitory; inhibitory products; chiral amines ... See more keywords
Mechanoenzymatic resolution of racemic chiral amines, a green technique for the synthesis of pharmaceutical building blocks
Sign Up to like & getrecommendations! Published in 2018 at "Tetrahedron"
DOI: 10.1016/j.tet.2018.09.029
Abstract: Abstract Very recently, several successful biocatalytic processes using mechanical activation to carry out enantioselective reactions have been reported. The present work describes the use of Candida antarctica Lipase B (CALB) in the kinetic resolution of… read more here.
Keywords: mechanoenzymatic resolution; racemic chiral; chiral amines; resolution racemic ... See more keywords
Reductive amination of ketones with ammonium catalyzed by a newly identified Brevibacterium epidermidis strain for the synthesis of (S)-chiral amines
Sign Up to like & getrecommendations! Published in 2018 at "Chinese Journal of Catalysis"
DOI: 10.1016/s1872-2067(18)63108-0
Abstract: Abstract The asymmetric reductive amination of achiral ketones with ammonia is a particularly attractive reaction for the synthesis of chiral amines. Although several engineered amine dehydrogenases have been developed by protein engineering for the asymmetric… read more here.
Keywords: synthesis chiral; chiral amines; amination ketones; reductive amination ... See more keywords
Recent Advances in the Enantioselective Synthesis of Chiral Amines via Transition Metal-Catalyzed Asymmetric Hydrogenation.
Sign Up to like & getrecommendations! Published in 2021 at "Chemical reviews"
DOI: 10.1021/acs.chemrev.1c00496
Abstract: Chiral amines are key structural motifs present in a wide variety of natural products, drugs, and other biologically active compounds. During the past decade, significant advances have been made with respect to the enantioselective synthesis… read more here.
Keywords: synthesis chiral; chiral amines; asymmetric hydrogenation; recent advances ... See more keywords
Local Electronic Charge Transfer in the Helical Induction of Cis-Transoid Poly(4-carboxyphenyl)acetylene by Chiral Amines
Sign Up to like & getrecommendations! Published in 2022 at "Journal of chemical information and modeling"
DOI: 10.1021/acs.jcim.1c01347
Abstract: Understanding the phenomena that lead to the formation of a specific helicity in helical polymers remains a challenge even today. Various polymers have been shown to assume different helical screw-senses depending on different stimuli. Acid-base… read more here.
Keywords: transoid poly; cis transoid; poly carboxyphenyl; induction ... See more keywords
Modular Access to Chiral Amines via Imine Reductase-Based Photoenzymatic Catalysis.
Sign Up to like & getrecommendations! Published in 2024 at "Journal of the American Chemical Society"
DOI: 10.1021/jacs.4c03879
Abstract: The development of catalysts serves as the cornerstone of innovation in synthesis, as exemplified by the recent discovery of photoenzymes. However, the repertoire of naturally occurring enzymes repurposed by direct light excitation to catalyze new-to-nature… read more here.
Keywords: chiral amines; imine; via imine; access chiral ... See more keywords
Enzymatic and chemo-enzymatic strategies to produce highly valuable chiral amines from biomass with ω-transaminases on 2D zeolites
Sign Up to like & getrecommendations! Published in 2022 at "National Science Review"
DOI: 10.1093/nsr/nwac135
Abstract: Abstract Amino transaminases (ATAs) have been supported on a 2D ITQ-2 zeolite through electrostatic interactions, resulting in a highly stable active biocatalyst to obtain a variety of valuable chiral amines starting from prochiral ketones derived… read more here.
Keywords: valuable chiral; biomass; chiral amines; enzymatic chemo ... See more keywords