Enantioseparation and molecular modeling study of chiral amines as three naphthaldimine derivatives using amylose or cellulose trisphenylcarbamate chiral stationary phases.
Sign Up to like & getrecommendations! Published in 2022 at "Chirality"
DOI: 10.1002/chir.23513
Abstract: This study describes the enantioseparation of three chiral amines as naphthaldimine derivatives, using normal phase HPLC with amylose and cellulose tris(3,5-dimethylphenylcarbamate) chiral stationary phases (CSPs). Three chiral amines were derivatized using three structurally similar naphthaldehyde… read more here.
Keywords: naphthaldimine derivatives; stationary phases; chiral amines; derivatives using ... See more keywords
In situ removal of inhibitory products with ion exchange resins for enhanced synthesis of chiral amines using ω-transaminase
Sign Up to like & getrecommendations! Published in 2020 at "Biochemical Engineering Journal"
DOI: 10.1016/j.bej.2020.107718
Abstract: Abstract ω-Transaminase (ω-TA) serves as an attractive biocatalyst for the asymmetric synthesis of chiral amines from prochiral ketones. However, the ω-TA reactions suffer from exceedingly unfavorable equilibrium and severe product inhibitions. Most reaction engineering strategies… read more here.
Keywords: synthesis chiral; removal inhibitory; inhibitory products; chiral amines ... See more keywords
Mechanoenzymatic resolution of racemic chiral amines, a green technique for the synthesis of pharmaceutical building blocks
Sign Up to like & getrecommendations! Published in 2018 at "Tetrahedron"
DOI: 10.1016/j.tet.2018.09.029
Abstract: Abstract Very recently, several successful biocatalytic processes using mechanical activation to carry out enantioselective reactions have been reported. The present work describes the use of Candida antarctica Lipase B (CALB) in the kinetic resolution of… read more here.
Keywords: mechanoenzymatic resolution; racemic chiral; chiral amines; resolution racemic ... See more keywords
Reductive amination of ketones with ammonium catalyzed by a newly identified Brevibacterium epidermidis strain for the synthesis of (S)-chiral amines
Sign Up to like & getrecommendations! Published in 2018 at "Chinese Journal of Catalysis"
DOI: 10.1016/s1872-2067(18)63108-0
Abstract: Abstract The asymmetric reductive amination of achiral ketones with ammonia is a particularly attractive reaction for the synthesis of chiral amines. Although several engineered amine dehydrogenases have been developed by protein engineering for the asymmetric… read more here.
Keywords: synthesis chiral; chiral amines; amination ketones; reductive amination ... See more keywords
Recent Advances in the Enantioselective Synthesis of Chiral Amines via Transition Metal-Catalyzed Asymmetric Hydrogenation.
Sign Up to like & getrecommendations! Published in 2021 at "Chemical reviews"
DOI: 10.1021/acs.chemrev.1c00496
Abstract: Chiral amines are key structural motifs present in a wide variety of natural products, drugs, and other biologically active compounds. During the past decade, significant advances have been made with respect to the enantioselective synthesis… read more here.
Keywords: synthesis chiral; chiral amines; asymmetric hydrogenation; recent advances ... See more keywords
Local Electronic Charge Transfer in the Helical Induction of Cis-Transoid Poly(4-carboxyphenyl)acetylene by Chiral Amines
Sign Up to like & getrecommendations! Published in 2022 at "Journal of chemical information and modeling"
DOI: 10.1021/acs.jcim.1c01347
Abstract: Understanding the phenomena that lead to the formation of a specific helicity in helical polymers remains a challenge even today. Various polymers have been shown to assume different helical screw-senses depending on different stimuli. Acid-base… read more here.
Keywords: transoid poly; cis transoid; poly carboxyphenyl; induction ... See more keywords
Enzymatic and chemo-enzymatic strategies to produce highly valuable chiral amines from biomass with ω-transaminases on 2D zeolites
Sign Up to like & getrecommendations! Published in 2022 at "National Science Review"
DOI: 10.1093/nsr/nwac135
Abstract: Abstract Amino transaminases (ATAs) have been supported on a 2D ITQ-2 zeolite through electrostatic interactions, resulting in a highly stable active biocatalyst to obtain a variety of valuable chiral amines starting from prochiral ketones derived… read more here.
Keywords: valuable chiral; biomass; chiral amines; enzymatic chemo ... See more keywords
Intensification of Double Kinetic Resolution of Chiral Amines and Alcohols via Chemoselective Formation of a Carbonate–Enzyme Intermediate
Sign Up to like & getrecommendations! Published in 2022 at "Molecules"
DOI: 10.3390/molecules27144346
Abstract: Chiral amines and alcohols are synthons of numerous pharmaceutically-relevant compounds. The previously developed enzymatic kinetic resolution approaches utilize a chiral racemic molecule and achiral acyl donor (or acyl acceptor). Thus, only one enantiodivergent step of… read more here.
Keywords: amines alcohols; resolution; chiral amines; enzyme ... See more keywords