Application of l-methionine γ-lyase in chiral amino acid analysis.
Sign Up to like & getrecommendations! Published in 2019 at "Analytical biochemistry"
DOI: 10.1016/j.ab.2019.05.018
Abstract: Here, a conventional chiral amino acid analysis method using high-performance liquid chromatography was coupled with a sample pretreatment using l-methionine γ-lyase from Pseudomonas putida ICR 3460 for the selective analysis of l-methionine and l-tryptophan. The… read more here.
Keywords: sample; chiral amino; methionine; methionine lyase ... See more keywords
Investigation of hydroxypropyl-β-cyclodextrin-based synergistic system with chiral nematic mesoporous silica as chiral stationary phase for enantiomeric separation in microchip electrophoresis.
Sign Up to like & getrecommendations! Published in 2020 at "Talanta"
DOI: 10.1016/j.talanta.2020.121121
Abstract: The separation of chiral amino acids using microchip electrophoresis (MCE) was investigated using chiral nematic mesoporous silica (CNMS) as the chiral stationary phase, with hydroxypropyl-β-cyclodextrin (HP-β-CD) as the chiral selector. Individually, neither CNMS nor HP-β-CD… read more here.
Keywords: amino acids; stationary phase; chiral stationary; separation ... See more keywords
Synthesis of syn-vicinal diamines via the stereoselective allylation of acyclic chiral α-amino aldimines
Sign Up to like & getrecommendations! Published in 2019 at "Tetrahedron Letters"
DOI: 10.1016/j.tetlet.2018.12.021
Abstract: Abstract The stereoselective allylation of acyclic chiral α-amino aldimines affording vicinal diamines, mediated by various Lewis acids (TiCl4, SnCl4, MgBr2·OEt2, BF3·OEt2, ZnCl2), is described. The TiCl4-mediated allylation of an α-N-Boc aldimine afforded the allylation product… read more here.
Keywords: allylation acyclic; amino aldimines; allylation; stereoselective allylation ... See more keywords
O-Allylhydroxyamine: A Bifunctional Olefin for Construction of Axially and Centrally Chiral Amino Alcohols via Asymmetric Carboamidation.
Sign Up to like & getrecommendations! Published in 2023 at "Journal of the American Chemical Society"
DOI: 10.1021/jacs.3c01162
Abstract: Difunctionalization of olefins offers an attractive approach to access complex chiral structures. Reported herein is the design of N-protected O-allylhydroxyamines as bifunctional olefins that undergo catalytic asymmetric 1,2-carboamidation with three classes of (hetero)arenes to afford… read more here.
Keywords: asymmetric carboamidation; chiral amino; alcohols via; amino ... See more keywords
Efficient access to chiral 1,2-amino alcohols via Ir/f-amphox-catalyzed asymmetric hydrogenation of α-amino ketones
Sign Up to like & getrecommendations! Published in 2017 at "Organic chemistry frontiers"
DOI: 10.1039/c7qo00237h
Abstract: Tridentate f-amphox ligands were successfully applied to the iridium-catalyzed asymmetric hydrogenation of various α-amino ketones to afford a series of chiral 1,2-amino alcohols with excellent results (all products up to >99% conversion and >99% ee,… read more here.
Keywords: amino ketones; catalyzed asymmetric; amino; asymmetric hydrogenation ... See more keywords
Iridium-catalyzed asymmetric double allylic alkylation of azlactone: efficient access to chiral α-amino acid derivatives.
Sign Up to like & getrecommendations! Published in 2022 at "Chemical communications"
DOI: 10.1039/d2cc00328g
Abstract: An unprecedented Ir-catalyzed enantioselective double allylic alkylation of less bulky cyclic imine glycinate (azlactone) was rationally designed and developed, providing various bisallylated chiral amino acid derivatives. Control experiments revealed that this transformation proceeds in a… read more here.
Keywords: chiral amino; amino acid; allylic alkylation; double allylic ... See more keywords
C-H amidation of 2-aryl azlactones under iridium(III) catalysis: access to chiral amino acids.
Sign Up to like & getrecommendations! Published in 2022 at "Chemical communications"
DOI: 10.1039/d2cc05245h
Abstract: In this study, we examine the site-selctive iridium(III)-catalyzed C-H amidation between 2-aryl azlactones and acyl azides. This transformation produces a range of ortho-amidated azlactones, which act as precursors for the synthesis of chiral amino acids… read more here.
Keywords: amino acids; iridium iii; chiral amino; aryl azlactones ... See more keywords
Self-Replication of Chiral α-Amino Acids in Strecker-Type Synthesis via Asymmetric Induction and Amplification of Their Own Chiral Intermediate α-Aminonitriles
Sign Up to like & getrecommendations! Published in 2019 at "Bulletin of the Chemical Society of Japan"
DOI: 10.1246/bcsj.20190116
Abstract: Self-replication is one of the essential characteristics of life, therefore, chemical reaction, in which biologically related chiral enantioenriched compounds can promote their own production, is a... read more here.
Keywords: self replication; amino acids; replication chiral; chiral amino ... See more keywords
Enzymatic Synthesis of 2-Chloropurine Arabinonucleosides with Chiral Amino Acid Amides at the C6 Position and an Evaluation of Antiproliferative Activity In Vitro
Sign Up to like & getrecommendations! Published in 2023 at "International Journal of Molecular Sciences"
DOI: 10.3390/ijms24076223
Abstract: A number of purine arabinosides containing chiral amino acid amides at the C6 position of the purine were synthesized using a transglycosylation reaction with recombinant E. coli nucleoside phosphorylases. Arsenolysis of 2-chloropurine ribosides with chiral… read more here.
Keywords: chiral amino; amino acid; synthesis; acid amides ... See more keywords
Chiral 8-Amino-5,6,7,8-tetrahydroquinoline Derivatives in Metal Catalysts for the Asymmetric Transfer Hydrogenation of 1-Aryl Substituted-3,4-dihydroisoquinolines as Alkaloids Precursors
Sign Up to like & getrecommendations! Published in 2023 at "Molecules"
DOI: 10.3390/molecules28041907
Abstract: Chiral diamines based on an 8-amino-5,6,7,8-tetrahydroquinoline backbone, known as CAMPY (L1), or the 2-methyl substituted analogue Me-CAMPY (L2) were employed as novel ligands in Cp* metal complexes for the ATH of a series of substituted… read more here.
Keywords: chiral amino; derivatives metal; metal catalysts; substituted dihydroisoquinolines ... See more keywords