Highly efficient synthesis of chiral aromatic ketones via Rh-catalyzed asymmetric hydrogenation of β,β-disubstituted enones.
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DOI: 10.1039/c7cc04045h
Abstract: A succinct and efficient protocol was developed for the synthesis of chiral aromatic ketones via asymmetric hydrogenation of β,β-disubstituted enones with rhodium catalysts based on chiral bisphosphine thiourea ligands. A series of substrates (17 examples)… read more here.
Keywords: ketones via; aromatic ketones; synthesis chiral; asymmetric hydrogenation ... See more keywords