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   Articles with "chiral biaryl" as a keyword



Construction of Axially Chiral Biaryl Sulfonamides by Palladium/Chiral Norbornene Cooperative Catalysis

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recommendations! Published in 2025 at "ChemCatChem"

DOI: 10.1002/cctc.202500560

Abstract: Aryl sulfonamide scaffold is a privileged pharmacophore, and is prevalent in pharmaceuticals. Existing aryl sulfonamide‐based pharmaceuticals are either achiral or limited to central chirality, leaving the potential of axially chiral biaryl sulfonamides underexplored. Beyond therapeutic… read more here.

Keywords: axially chiral; palladium chiral; chiral norbornene; biaryl sulfonamides ... See more keywords

Trigonostemons G and H, dinorditerpenoid dimers with axially chiral biaryl linkage from Trigonostemon chinensis.

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recommendations! Published in 2020 at "Chirality"

DOI: 10.1002/chir.23170

Abstract: Trigonostemons G and H, two novel dimeric dinorditerpenoids, were isolated from the stem barks of Trigonostemon chinensis. Their planar structures and relative configurations were established by extensive analysis of spectroscopic data. Trigonostemons G and H… read more here.

Keywords: biaryl; chiral biaryl; biaryl linkage; trigonostemon chinensis ... See more keywords

Organocatalytic Asymmetric Arylation of p-Quinone Phosphonates: A Green Access to Biaryl Monophosphorus Ligands.

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recommendations! Published in 2021 at "Organic letters"

DOI: 10.1021/acs.orglett.1c02852

Abstract: Herein, we report a highly efficient organocatalytic asymmetric synthesis of axially chiral biaryl phosphonates with p-quinone phosphonates and 2-naphthols via CPA-catalyzed asymmetric arylations. A series of chiral biaryl monophosphonates were obtained in excellent yields and… read more here.

Keywords: chiral biaryl; biaryl; organocatalytic asymmetric; biaryl monophosphorus ... See more keywords

Organocatalytic asymmetric N-sulfonyl amide C-N bond activation to access axially chiral biaryl amino acids

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recommendations! Published in 2020 at "Nature Communications"

DOI: 10.1038/s41467-020-14799-8

Abstract: Amides are among the most fundamental functional groups and essential structural units, widely used in chemistry, biochemistry and material science. Amide synthesis and transformations is a topic of continuous interest in organic chemistry. However, direct… read more here.

Keywords: biaryl; chiral biaryl; amino acids; axially chiral ... See more keywords

Atroposelective brominations to access chiral biaryl scaffolds using high-valent Pd-catalysis

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recommendations! Published in 2023 at "Chemical Science"

DOI: 10.1039/d2sc06131g

Abstract: Compounds featuring atropisomerism are ubiquitous in natural products, therapeutics, advanced materials, and asymmetric synthesis. However, stereoselective preparation of these compounds presents many synthetic challenges. This article introduces streamlined access to a versatile chiral biaryl template… read more here.

Keywords: chiral biaryl; valent catalysis; access; high valent ... See more keywords