Trigonostemons G and H, dinorditerpenoid dimers with axially chiral biaryl linkage from Trigonostemon chinensis.
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DOI: 10.1002/chir.23170
Abstract: Trigonostemons G and H, two novel dimeric dinorditerpenoids, were isolated from the stem barks of Trigonostemon chinensis. Their planar structures and relative configurations were established by extensive analysis of spectroscopic data. Trigonostemons G and H… read more here.
Keywords: biaryl; chiral biaryl; biaryl linkage; trigonostemon chinensis ... See more keywords
Organocatalytic Asymmetric Arylation of p-Quinone Phosphonates: A Green Access to Biaryl Monophosphorus Ligands.
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DOI: 10.1021/acs.orglett.1c02852
Abstract: Herein, we report a highly efficient organocatalytic asymmetric synthesis of axially chiral biaryl phosphonates with p-quinone phosphonates and 2-naphthols via CPA-catalyzed asymmetric arylations. A series of chiral biaryl monophosphonates were obtained in excellent yields and… read more here.
Keywords: chiral biaryl; biaryl; organocatalytic asymmetric; biaryl monophosphorus ... See more keywords
Organocatalytic asymmetric N-sulfonyl amide C-N bond activation to access axially chiral biaryl amino acids
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DOI: 10.1038/s41467-020-14799-8
Abstract: Amides are among the most fundamental functional groups and essential structural units, widely used in chemistry, biochemistry and material science. Amide synthesis and transformations is a topic of continuous interest in organic chemistry. However, direct… read more here.
Keywords: biaryl; chiral biaryl; amino acids; axially chiral ... See more keywords
Atroposelective brominations to access chiral biaryl scaffolds using high-valent Pd-catalysis
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DOI: 10.1039/d2sc06131g
Abstract: Compounds featuring atropisomerism are ubiquitous in natural products, therapeutics, advanced materials, and asymmetric synthesis. However, stereoselective preparation of these compounds presents many synthetic challenges. This article introduces streamlined access to a versatile chiral biaryl template… read more here.
Keywords: chiral biaryl; valent catalysis; access; high valent ... See more keywords