Copper‐Catalyzed Desymmetric Alkyne–Azide Cycloaddition to Access Axially Chiral Biaryls
Sign Up to like & getrecommendations! Published in 2025 at "European Journal of Organic Chemistry"
DOI: 10.1002/ejoc.202500041
Abstract: Axially chiral biaryls are an important class of structural units widely used in natural product synthesis, drug design, and as ligands for asymmetric catalysis. Although significant progress has been made in the synthesis of axially… read more here.
Keywords: axially chiral; chiral biaryls; alkyne; biaryls ... See more keywords
Accessing Axially Chiral Biaryls via Organocatalytic Enantioselective Dynamic-Kinetic Resolution-Semipinacol Rearrangement
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DOI: 10.1021/acscatal.7b01056
Abstract: We have developed a synthetic strategy to access axially chiral biaryls through a dynamic-kinetic resolution-semipinacol rearrangement process. The axial chirality together with a sp3 quaternary carbon can be introduced in a single chemical operation. The… read more here.
Keywords: resolution semipinacol; kinetic resolution; semipinacol rearrangement; dynamic kinetic ... See more keywords
Synthesis of Axially Chiral Biaryls via Pd(II)-Catalysed Direct C(sp2)-H Arylation
Sign Up to like & getrecommendations! Published in 2024 at "Organic Chemistry Frontiers"
DOI: 10.1039/d4qo00958d
Abstract: A concise protocol for the construction of axially chiral biaryls via Pd-catalyzed direct C-H arylation of 1-arylisoquinoline N-oxides through kinetic resolution using commercially available, cost-effective, and bench-stable chiral mono-protected amino... read more here.
Keywords: axially chiral; synthesis axially; chiral biaryls; arylation ... See more keywords