Recyclable Chiral Bifunctional Thioureas Derived from [60]Fullerene and Their Use as Highly Efficient Organocatalysts for the Asymmetric Nitro-Michael Reaction
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DOI: 10.1002/ejoc.201601640
Abstract: Three novel fullerothioureas derived from natural valine, phenylalanine, and tert-leucine have been prepared by Prato's reaction of [60]fullerene and the corresponding aldehydes. These hybrids have been used as organocatalysts in a typical stereoselective nitro-Michael addition… read more here.
Keywords: nitro michael; recyclable chiral; chiral bifunctional; bifunctional thioureas ... See more keywords
Synthesis of Chiral Bifunctional NHC Ligands and Survey of Their Utilities in Asymmetric Gold Catalysis.
Sign Up to like & getrecommendations! Published in 2019 at "Organometallics"
DOI: 10.1021/acs.organomet.9b00400
Abstract: The synthesis and characterization of the chiral bifunctional NHC ligands based on the imidazo[1,5-a]pyridine (ImPy) scaffold are described. These ligands possess a fluxional biaryl axis and a chiral center. The configurational stability of the biaryl… read more here.
Keywords: bifunctional nhc; chiral bifunctional; gold catalysis; nhc ligands ... See more keywords
Chiral Bifunctional Phosphine Ligand Enables Gold-Catalyzed Asymmetric Isomerization and Cyclization of Propargyl Sulfonamide into Chiral 3-Pyrroline.
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DOI: 10.1021/acs.orglett.1c02896
Abstract: This work details an asymmetric gold-ligand cooperative catalysis that transforms readily accessible chiral/achiral propargylic sulfonamides into chiral 3-pyrrolines. A bifunctional biphenyl-2-ylphosphine ligand featuring a chiral tetrahydroisoquinoline fragment is essential for the observed metal-ligand cooperation and… read more here.
Keywords: ligand enables; bifunctional phosphine; chiral bifunctional; enables gold ... See more keywords
Design of Efficient Chiral Bifunctional Phase-Transfer Catalysts Possessing an Amino Functionality for Asymmetric Aminations
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DOI: 10.1021/acscatal.8b03292
Abstract: An efficient, chiral bifunctional phase-transfer catalyst with an intramolecular amino functionality has been designed and successfully applied to highly enantioselective amination of 3-aryloxindoles and 3-arylbenzofuran-2(3H)-ones with bis(adamantyl) azodicarboxylate. Optically active amination products were generally obtained… read more here.
Keywords: chiral bifunctional; phase transfer; efficient chiral; bifunctional phase ... See more keywords
Development of Chiral, Bifunctional Thiosquaramides: Enantioselective Michael Additions of Barbituric Acids to Nitroalkenes.
Sign Up to like & getrecommendations! Published in 2017 at "Journal of the American Chemical Society"
DOI: 10.1021/jacs.7b01115
Abstract: We report a general method for the synthesis of chiral thiosquaramides, a class of bifunctional catalysts not previously described in the literature. Thiosquaramides are found to be more acidic and significantly more soluble in nonpolar… read more here.
Keywords: thiosquaramides enantioselective; chiral bifunctional; enantioselective michael; bifunctional thiosquaramides ... See more keywords
Chiral Bifunctional N, N, P-Ligand-Enabled Cooperative Cu Catalysis: One-Pot Two-Step Propargylic Substitution of Propargylic Alcohols
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DOI: 10.1039/d5qo00595g
Abstract: Propargyl moieties are important structural features that are ubiquitously found in numerous natural products and pharmaceutical molecules. Due to the high reaction barrier, copper-catalyzed enantioselective propargylation with propargylic alcohol has... read more here.
Keywords: cooperative catalysis; ligand enabled; catalysis one; bifunctional ligand ... See more keywords
Chiral Bifunctional Photocatalysts with Aromatic Ketones as Photosensitizers.
Sign Up to like & getrecommendations! Published in 2025 at "Chimia"
DOI: 10.2533/chimia.2025.803
Abstract: Because the biological activity of a molecule is directly linked to its three-dimensional configuration, the preparation of chiral compounds is a central discipline in synthetic organic chemistry. With the exploitation of photoredox catalysis that gives… read more here.
Keywords: chemistry; ketones photosensitizers; photocatalysts aromatic; aromatic ketones ... See more keywords
Chiral bifunctional sulfide-catalyzed enantioselective bromolactonizations of α- and β-substituted 5-hexenoic acids
Sign Up to like & getrecommendations! Published in 2024 at "Beilstein Journal of Organic Chemistry"
DOI: 10.3762/bjoc.20.158
Abstract: Enantioselective halolactonizations of sterically less hindered alkenoic acid substrates without substituents on the carbon–carbon double bond have remained a formidable challenge. To address this limitation, we report herein the asymmetric bromolactonization of 5-hexenoic acid derivatives… read more here.
Keywords: catalyzed enantioselective; sulfide catalyzed; bifunctional sulfide; enantioselective bromolactonizations ... See more keywords