Crown Ether-Derived Chiral BINOL: Enantioselective Michael Addition of Alkenyl Boronic Acids to α,β-Unsaturated Ketones
Sign Up to like & getrecommendations! Published in 2021 at "ACS Omega"
DOI: 10.1021/acsomega.1c05875
Abstract: A new class of aza-crown ether-derived chiral BINOL catalysts were designed, synthesized, and applied in the asymmetric Michael addition of alkenylboronic acids to α,β-unsaturated ketones. It was found that introducing aza-crown ethers to the BINOL… read more here.
Keywords: derived chiral; ether derived; chiral binol; crown ether ... See more keywords
Chiral BINOL-based borate counterions: from cautionary tale on anion stability to enantioselective Cu-catalyzed cyclopropanation.
Sign Up to like & getrecommendations! Published in 2022 at "Chemical communications"
DOI: 10.1039/d2cc05924j
Abstract: The chiral weakly coordinating (3,3'-biphenyl-BINOL)BF2 anion can be generated by the reaction of the BINOL derivative with Cu(NCMe)4BF4. Structural analysis suggest the anion is weakly coordinating to Cu+. However, its use in cyclopropanation reactions leads… read more here.
Keywords: based borate; binol; cyclopropanation; binol based ... See more keywords