Modular Design of Chiral Conjugate-Base-Stabilized Carboxylic Acids: Catalytic Enantioselective [4+2] Cycloadditions of Acetals.
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DOI: 10.1021/jacs.0c07212
Abstract: Readily available 1,2-amino alcohols provide the framework for a new generation of chiral carboxylic acid catalysts that rival the acidity of the widely used chiral phosphoric acid catalyst (S)-TRIP. Covalently linked thiourea sites stabilize the… read more here.
Keywords: chiral conjugate; modular design; conjugate; design chiral ... See more keywords