Highly Enantioselective Synthesis of Chiral Cyclopropyl Nucleosides via Catalytic Asymmetric Intermolecular Cyclopropanation.
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DOI: 10.1021/acs.orglett.7b03110
Abstract: An efficient route to construct chiral cyclopropyl purine nucleoside analogues has been established via the catalytic asymmetric Michael-initiated ring-closure reactions of α-purine acrylates with α-bromo-carboxylic esters. Using (DHQD)2AQN as the catalyst, various chiral cyclopropyl purine… read more here.
Keywords: via catalytic; cyclopropyl; chiral cyclopropyl; cyclopropyl purine ... See more keywords