Chiral Derivatives of Xanthones: Investigation of the Effect of Enantioselectivity on Inhibition of Cyclooxygenases (COX-1 and COX-2) and Binding Interaction with Human Serum Albumin
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DOI: 10.3390/ph10020050
Abstract: Searching of new enantiomerically pure chiral derivatives of xanthones (CDXs) with potential pharmacological properties, particularly those with anti-inflammatory activity, has remained an area of interest of our group. Herein, we describe in silico studies and… read more here.
Keywords: chiral derivatives; cyclooxygenases cox; inhibition; cox ... See more keywords
Enantioselectivity of Chiral Derivatives of Xanthones in Virulence Effects of Resistant Bacteria
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DOI: 10.3390/ph14111141
Abstract: Antimicrobial peptides are one of the lines of defense produced by several hosts in response to bacterial infections. Inspired by them and recent discoveries of xanthones as bacterial efflux pump inhibitors, chiral amides with a… read more here.
Keywords: chiral derivatives; xanthones virulence; enantioselectivity chiral; efflux pumps ... See more keywords