A Condensation/Reductive Alkylation/Hydrogenation Cascade for Facile Synthesis of Chiral 2,3‐Disubstituted Indolines
Sign Up to like & getrecommendations! Published in 2019 at "Asian Journal of Organic Chemistry"
DOI: 10.1002/ajoc.201900289
Abstract: A divergent and enantioselective procedure for synthesis of 2,3-disubstituted indolines was developed through Brønsted acid/palladium-complex promoted condensation/reductive alkylation/ hydrogenation cascade reactions from simple amino ketones and aldehydes in one operation. Five Brønsted acid-promoted steps and… read more here.
Keywords: disubstituted indolines; chiral disubstituted; synthesis; nsted acid ... See more keywords
Nickel-Catalyzed Asymmetric Propargylation for the Synthesis of Axially Chiral 1,3-Disubstituted Allenes.
Sign Up to like & getrecommendations! Published in 2022 at "Journal of the American Chemical Society"
DOI: 10.1021/jacs.2c10863
Abstract: The general enantioselective catalytic synthesis of axially chiral 1,3-disubstituted allenes from readily available racemic propargylic alcohol derivatives remains a long-standing challenge in organic synthesis. Here we report an efficient nickel-catalyzed asymmetric propargylic substitution reaction/Myers rearrangement… read more here.
Keywords: disubstituted allenes; nickel catalyzed; synthesis; axially chiral ... See more keywords
Enzyme catalysed Pictet-Spengler formation of chiral 1,1'-disubstituted- and spiro-tetrahydroisoquinolines
Sign Up to like & getrecommendations! Published in 2017 at "Nature Communications"
DOI: 10.1038/ncomms14883
Abstract: The Pictet–Spengler reaction (PSR) involves the condensation and ring closure between a β-arylethylamine and a carbonyl compound. The combination of dopamine and ketones in a PSR leads to the formation of 1,1′-disubstituted tetrahydroisoquinolines (THIQs), structures… read more here.
Keywords: chiral disubstituted; pictet spengler; enzyme catalysed; disubstituted spiro ... See more keywords