Copper-Catalyzed Enantioselective 1,4-Protosilylation of Alkynyl-substituted Enones to Synthesize the Highly Diastereomeric Chiral Homoallenylsilanes.
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DOI: 10.1021/acs.orglett.2c00739
Abstract: A copper-catalyzed 1,4-protosilylation of α-alkynyl-enones to form the functionalized chiral homoallenylsilanes was developed. In the presence of a chiral monopyridine oxazoline ligand, a variety of trisubstituted allene derivatives bearing a contiguous stereogenic center and axis… read more here.
Keywords: copper catalyzed; catalyzed enantioselective; chiral homoallenylsilanes; protosilylation alkynyl ... See more keywords