Asymmetric formation of γ-lactams via C–H amidation enabled by chiral hydrogen-bond-donor catalysts
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DOI: 10.1038/s41929-019-0230-x
Abstract: Chiral γ-lactams are effective structural motifs found in numerous pharmaceutical agents. Despite their importance, current approaches mostly necessitate laborious synthetic steps employing pre-functionalized starting materials under demanding conditions. In this regard, asymmetric C−H amidation can… read more here.
Keywords: chiral hydrogen; hydrogen; hydrogen bond; bond donor ... See more keywords