Construction of Axially Chiral Biaryl Sulfonamides by Palladium/Chiral Norbornene Cooperative Catalysis
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DOI: 10.1002/cctc.202500560
Abstract: Aryl sulfonamide scaffold is a privileged pharmacophore, and is prevalent in pharmaceuticals. Existing aryl sulfonamide‐based pharmaceuticals are either achiral or limited to central chirality, leaving the potential of axially chiral biaryl sulfonamides underexplored. Beyond therapeutic… read more here.
Keywords: axially chiral; palladium chiral; chiral norbornene; biaryl sulfonamides ... See more keywords
"De Novo" Construction of Planar-Chiral Ferrocenes via Palladium/Chiral Norbornene Cooperative Catalysis.
Sign Up to like & getrecommendations! Published in 2025 at "Journal of the American Chemical Society"
DOI: 10.1021/jacs.5c13420
Abstract: Transition-metal-catalyzed asymmetric C-H functionalization has emerged as a powerful strategy for constructing planar-chiral ferrocenes (PCFs). However, current methods typically require preinstallation of a directing group (DG) and are usually limited to monofunctionalization. Herein, we report… read more here.
Keywords: novo construction; cooperative catalysis; planar chiral; chiral norbornene ... See more keywords