Chiral Brønsted acid catalyzed asymmetric oxidation of N-acyl sulfenamide by H2 O2 : An efficient approach to obtaining chiral N-acyl sulfinamide.
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DOI: 10.1002/chir.23478
Abstract: Although the power of chiral sulfinamide reagents in synthetic chemistry has long been recognized, methods for their synthesis are still auxiliary-based approaches which possess the disadvantages of poor atom economy and limited substrate universality. Due… read more here.
Keywords: chiral nsted; catalyzed asymmetric; nsted acid; acid ... See more keywords
Ln(III)/Chiral Brønsted Acid Catalyzed Asymmetric Cascade Ring Opening/Aza-Piancatelli Rearrangement of D-A Cyclopropanes.
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DOI: 10.1021/acs.orglett.0c03413
Abstract: The first Lewis acid and chiral Brønsted acid cooperatively catalyzed asymmetric cascade ring opening/aza-Piancatelli rearrangement reaction of furyl-substituted donor-acceptor cyclopropanes is achieved, enabling the construction of functionalized aminocyclopentenones bearing α-quaternary carbon stereocenters in high yields… read more here.
Keywords: catalyzed asymmetric; ring opening; nsted acid; chiral nsted ... See more keywords
Chiral Brønsted Acid-Catalyzed Intramolecular Asymmetric Allylic Alkylation of Indoles with Primary Alcohols.
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DOI: 10.1021/acs.orglett.2c01253
Abstract: Herein, chiral Brønsted acid-catalyzed intramolecular asymmetric allylic alkylation of indoles with allylic primary alcohols is described. The allyl alcohols were directly employed as the allylic precursors in this metal-free protocol, without preactivation or any additional… read more here.
Keywords: intramolecular asymmetric; catalyzed intramolecular; chiral nsted; nsted acid ... See more keywords
Chiral Brønsted acid-catalyzed dynamic kinetic resolution of atropisomeric ortho-formyl naphthamides.
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DOI: 10.1039/d0cc02380a
Abstract: Despite the widespread use of naphthamide atropisomers in biologically active compounds and asymmetric catalysis, few catalytic methods have succeeded in the enantioselective synthesis of these compounds. Herein, a chiral Brønsted acid (CBA) catalysis strategy was… read more here.
Keywords: nsted acid; chiral nsted; kinetic resolution; dynamic kinetic ... See more keywords
Chiral Brønsted Acids Catalyze Asymmetric Additions to Substrates that Are Already Protonated: Highly Enantioselective Disulfonimide-Catalyzed Hantzsch Ester Reductions of NH–Imine Hydrochloride Salts
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DOI: 10.1055/s-0040-1706413
Abstract: While imines are frequently used substrates in asymmetric Bronsted acid catalysis, their corresponding salts are generally considered unsuitable reaction partners. Such processes are challenging because they require the successful competition of a catalytic amount of… read more here.
Keywords: acids catalyze; chiral nsted; imine hydrochloride; nsted acids ... See more keywords