Chiral piperidines from acyclic amines via enantioselective, radical-mediated δ C-H cyanation.
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DOI: 10.1016/j.chempr.2019.09.010
Abstract: Piperidines are the most prevalent heterocycle found in medicines. Yet, while they are often chiral, there remain no robust methods for their asymmetric syntheses. To solve this challenge, we have interrupted the century-old Hofmann-Löffler-Freytag (HLF)… read more here.
Keywords: piperidines acyclic; chiral piperidines; amines via; cyanation ... See more keywords