Synthesis of chiral polycyclic N-heterocycles via gold(I)-catalyzed 1,6-enyne cyclization/intramolecular nucleophilic addition.
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DOI: 10.1039/d1cc06388j
Abstract: Cycloisomerization of N-tethered indole- and dihydropyrrole-arylpropargyl substrates into complex polycycles was investigated by using gold(I) catalysis. Enantioselectivities up to 93% ee were obtained in the asymmetric version of this process. DFT calculations rationalized the reactivity… read more here.
Keywords: heterocycles via; polycyclic heterocycles; synthesis chiral; chiral polycyclic ... See more keywords