Reinvigorating the Chiral Pool: Chemoenzymatic Approaches to Complex Peptides and Terpenoids.
Sign Up to like & getrecommendations! Published in 2021 at "Accounts of chemical research"
DOI: 10.1021/acs.accounts.0c00823
Abstract: ConspectusBiocatalytic transformations that leverage the selectivity and efficiency of enzymes represent powerful tools for the construction of complex natural products. Enabled by innovations in genome mining, bioinformatics, and enzyme engineering, synthetic chemists are now more… read more here.
Keywords: natural products; reinvigorating chiral; pool; chiral pool ... See more keywords
C-C Bond Cleavage of α-Pinene Derivatives Prepared from Carvone as a General Strategy for Complex Molecule Synthesis.
Sign Up to like & getrecommendations! Published in 2022 at "Accounts of chemical research"
DOI: 10.1021/acs.accounts.1c00783
Abstract: ConspectusThe preparation of complex molecules (e.g., biologically active secondary metabolites) remains an important pursuit in chemical synthesis. By virtue of their sophisticated architectures, complex natural products inspire total synthesis campaigns that can lead to completely… read more here.
Keywords: cleavage; structure; chiral pool; synthesis ... See more keywords
Navigating the Chiral Pool in the Total Synthesis of Complex Terpene Natural Products.
Sign Up to like & getrecommendations! Published in 2017 at "Chemical reviews"
DOI: 10.1021/acs.chemrev.6b00834
Abstract: The pool of abundant chiral terpene building blocks (i.e., "chiral pool terpenes") has long served as a starting point for the chemical synthesis of complex natural products, including many terpenes themselves. As inexpensive and versatile… read more here.
Keywords: natural products; pool; terpene; chiral pool ... See more keywords
Jumping in the Chiral Pool: Asymmetric Hydroaminations with Early Metals
Sign Up to like & getrecommendations! Published in 2023 at "Molecules"
DOI: 10.3390/molecules28062702
Abstract: The application of early-metal-based catalysts featuring natural chiral pool motifs, such as amino acids, terpenes and alkaloids, in hydroamination reactions is discussed and compared to those beyond the chiral pool. In particular, alkaline (Li), alkaline… read more here.
Keywords: chiral pool; hydroaminations early; jumping chiral; pool ... See more keywords