Advances and applications of chiral resolution in pharmaceutical field.
Sign Up to like & getrecommendations! Published in 2022 at "Chirality"
DOI: 10.1002/chir.23453
Abstract: The attention to chiral drugs has been raised to an unprecedented level as drug discovery and development strategies grow rapidly. However, separation of enantiomers is still a huge task, which leads to an increasing significance… read more here.
Keywords: chemistry; chiral resolution; applications chiral; resolution ... See more keywords
Application of 2D EXSY and qNMR Spectroscopy for Diastereomeric Excess Determination Following Chiral Resolution of β‐Lactams
Sign Up to like & getrecommendations! Published in 2022 at "ChemistryOpen"
DOI: 10.1002/open.202200119
Abstract: Abstract Trans‐β‐lactam isomers have garnered much attention as anti‐cancer microtubule targeting agents. Currently available synthetic methods are available for the preparation of enantiopure β‐lactams and favour isomeric cis/trans β‐lactam mixtures. Indirect chiral resolution offers the… read more here.
Keywords: spectroscopy; chiral resolution; resolution lactams; resolution ... See more keywords
Chiral resolution, absolute configuration, and bioactivity of a new racemic asarone derivative from the rhizome of Acorus tatarinowii.
Sign Up to like & getrecommendations! Published in 2017 at "Fitoterapia"
DOI: 10.1016/j.fitote.2017.08.004
Abstract: A new asarone-derived racemate (1) was isolated from the rhizome of Acorus tatarinowii. The structure of 1 was established by comprehensive spectroscopic analyses, and it was successfully resolved by chiral HPLC, demonstrating that it is… read more here.
Keywords: asarone; chiral resolution; rhizome acorus; acorus tatarinowii ... See more keywords
Reversible Stereodivergent Cycloaddition of Racemic Helicenes to [60]Fullerene: A Chiral Resolution Strategy.
Sign Up to like & getrecommendations! Published in 2018 at "Organic letters"
DOI: 10.1021/acs.orglett.8b00256
Abstract: [60]Fullerene and its rarely explored reversible covalent chemistry have been harnessed as an efficient alternative for the chiral resolution of racemates. By using only catalytic amounts of chiral agents, stereodivergent 1,3-dipolar cycloadditions of racemic helicenes… read more here.
Keywords: reversible stereodivergent; racemic helicenes; chiral resolution; stereodivergent cycloaddition ... See more keywords
Reversible crystal-to-crystal chiral resolution: making/breaking non-bonding SO interactions.
Sign Up to like & getrecommendations! Published in 2017 at "Chemical communications"
DOI: 10.1039/c7cc00907k
Abstract: An achiral organic molecule adopts a chiral conformation, crystallizing in two morphologies: a racemic form, stable 90% of the time from the melt. read more here.
Keywords: crystal crystal; reversible crystal; resolution making; chiral resolution ... See more keywords
Crystal structure of a protein-aromatic foldamer composite: macromolecular chiral resolution.
Sign Up to like & getrecommendations! Published in 2019 at "Chemical communications"
DOI: 10.1039/c9cc05330a
Abstract: Co-crystallization of a 2 kDa tether-free sulfonated foldamer and the 13 kDa lysine-rich cytochrome c yielded a remarkable biohybrid assembly with chiral resolution of the foldamer helix handedness. In the crystal a ∼5 nm foldamer… read more here.
Keywords: crystal structure; foldamer; structure protein; chiral resolution ... See more keywords
Enantioselective Mixed Matrix Membranes for Chiral Resolution
Sign Up to like & getrecommendations! Published in 2021 at "Membranes"
DOI: 10.3390/membranes11040279
Abstract: Most pharmaceuticals are stereoisomers that each enantiomer shows dramatically different biological activity. Therefore, the production of optically pure chemicals through sustainable and energy-efficient technology is one of the main objectives in the pharmaceutical industry. Membrane-based… read more here.
Keywords: mixed matrix; enantioselective mixed; matrix membranes; chiral resolution ... See more keywords
Homochiral Metal-Organic Framework Based Mixed Matrix Membrane for Chiral Resolution
Sign Up to like & getrecommendations! Published in 2022 at "Membranes"
DOI: 10.3390/membranes12040357
Abstract: Efficient separation of enantiomers is critical in the chemical, pharmaceutical, and food industries. However, conventional separation methods, such as chromatography, crystallization, and enzymatic kinetic resolution, require high energy costs and specific reaction conditions for the… read more here.
Keywords: homochiral metal; mixed matrix; chiral resolution; matrix membrane ... See more keywords
Synthesis, Chiral Resolution and Enantiomers Absolute Configuration of 4-Nitropropranolol and 7-Nitropropranolol
Sign Up to like & getrecommendations! Published in 2022 at "Molecules"
DOI: 10.3390/molecules28010057
Abstract: We recently identified 6-nitrodopamine and other nitro-catecholamines (6-nitrodopa, 6-nitroadrenaline), indicating that the endothelium has the ability to nitrate the classical catecholamines (dopamine, noradrenaline, and adrenaline). In order to investigate whether drugs could be subject to… read more here.
Keywords: configuration; absolute configuration; chiral resolution; synthesis chiral ... See more keywords