Formal Asymmetric Cycloaddition of Activated α,β-Unsaturated Ketones with α-Diazomethylphosphonate Mediated by a Chiral Silver SPINOL Phosphate Catalyst.
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DOI: 10.1021/acs.orglett.8b03436
Abstract: An efficient method for preparing highly functionalized chiral nonspiro-phosphonylpyrazolines via an asymmetric formal 1,3-dipolar cycloaddition reaction of α-diazomethylphosphonate with activated, acyclic α,β-unsaturated ketones, bearing an additional nitrile electron-withdrawing group, has been developed, utilizing an in… read more here.
Keywords: diazomethylphosphonate; cycloaddition; unsaturated ketones; phosphate catalyst ... See more keywords