Rh-Catalyzed Asymmetric Hydrogenation of 2-Substituted 4H-(Thio)chromenes for Synthesis of Chiral (Thio)chromanes.
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DOI: 10.1021/acs.orglett.4c01808
Abstract: Rh-catalyzed asymmetric hydrogenation of 2-substituted 4H-thiochromenes and 4H-chromenes was successfully developed. This method provided highly efficient access to a series of chiral 2-substituted thiochromanes and chromanes in high yields with excellent enantioselectivities (up to 99%… read more here.
Keywords: hydrogenation substituted; chiral substituted; hydrogenation; synthesis chiral ... See more keywords
Diastereo- and Enantioselective Catalytic Kinetic Resolution of 2-Substituted 3-Nitro-2H-chromenes.
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DOI: 10.1021/acs.orglett.5c00903
Abstract: An unprecedented catalytic kinetic resolution of 2-substituted 3-nitro-2H-chromenes via Rh-catalyzed asymmetric hydrogenation has been developed to simultaneously produce a variety of syn-chiral 2-substituted 3-nitro-2H-chromanes containing vicinal stereogenic centers with excellent diastero- and enantioselectivities [diastereomeric ratio… read more here.
Keywords: nitro chromenes; chiral substituted; substituted nitro; catalytic kinetic ... See more keywords
Electroenzymatic Cascade Synthesis of Chiral α-Substituted Aromatic Halohydrins from Alkene: A Green and Stereoselective Approach
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DOI: 10.1039/d5gc04446d
Abstract: Chiral α-substituted aromatic halohydrins are vital intermediates in pharmaceutical development and asymmetric synthesis. Herein, we report a sustainable electroenzymatic cascade for their synthesis directly from alkene. This one-pot strategy integrates... read more here.
Keywords: electroenzymatic cascade; chiral substituted; aromatic halohydrins; cascade synthesis ... See more keywords