Enantioresolution and stereochemical characterization of two chiral sulfoxides endowed with COX-2 inhibitory activity.
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DOI: 10.1002/chir.22724
Abstract: The capacity of nonsteroidal antiinflammatory drugs (NSAIDs) to prevent prostanoids biosynthesis through the inhibition of COX-2 enzyme is related to their structural backbone, based on the fusion of a cis-stilbene unit with a variety of… read more here.
Keywords: chiral sulfoxides; two chiral; characterization two; enantioresolution stereochemical ... See more keywords
Discovery and Rational Mutagenesis of Methionine Sulfoxide Reductase Biocatalysts To Expand the Substrate Scope of the Kinetic Resolution of Chiral Sulfoxides
Sign Up to like & getrecommendations! Published in 2023 at "ACS Catalysis"
DOI: 10.1021/acscatal.3c00372
Abstract: Methionine sulfoxide reductase A (MsrA) enzymes have recently found applications as nonoxidative biocatalysts in the enantioselective kinetic resolution of racemic sulfoxides. This work describes the identification of selective and robust MsrA biocatalysts able to catalyze… read more here.
Keywords: chiral sulfoxides; expand substrate; sulfoxide reductase; resolution ... See more keywords
Chiral sulfoxides: advances in asymmetric synthesis and problems with the accurate determination of the stereochemical outcome.
Sign Up to like & getrecommendations! Published in 2018 at "Chemical Society reviews"
DOI: 10.1039/c6cs00703a
Abstract: Chiral sulfoxides are in extremely high demand in nearly every sector of the chemical industry concerned with the design and development of new synthetic reagents, drugs, and functional materials. The primary objective of this review… read more here.
Keywords: chiral sulfoxides; determination stereochemical; chemistry; accurate determination ... See more keywords
Enzymatic kinetic resolution of chiral sulfoxides - an enantiocomplementary approach.
Sign Up to like & getrecommendations! Published in 2019 at "Chemical communications"
DOI: 10.1039/c9cc05470g
Abstract: A new enzymatic assay for the preparation of chiral sulfoxides that is enantiocomplementary to the known (S)-enantiomer-reducing activity of methionine sulfoxide reductase A (MsrA) is described. To this end, we have utilized the enzyme DMSO… read more here.
Keywords: sulfoxides enantiocomplementary; chiral sulfoxides; enantiocomplementary approach; kinetic resolution ... See more keywords
Discovery of Two Native Baeyer-Villiger Monooxygenases for Asymmetric Synthesis of Bulky Chiral Sulfoxides
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DOI: 10.1128/aem.00638-18
Abstract: ABSTRACT Two Baeyer-Villiger monooxygenases (BVMOs), designated BoBVMO and AmBVMO, were discovered from Bradyrhizobium oligotrophicum and Aeromicrobium marinum, respectively. Both monooxygenases displayed novel features for catalyzing the asymmetric sulfoxidation of bulky and pharmaceutically relevant thioethers. Evolutionary… read more here.
Keywords: baeyer; chiral sulfoxides; bulky; baeyer villiger ... See more keywords