Pyrrolidines and piperidines bearing chiral tertiary alcohols by nickel-catalyzed enantioselective reductive cyclization of N-alkynones
Sign Up to like & getrecommendations! Published in 2018 at "Communications Chemistry"
DOI: 10.1038/s42004-018-0092-1
Abstract: Pyrrolidines and piperidines are important building blocks in organic synthesis. Numerous methods exist for constructing substituted pyrrolidines and piperidines. However, efficient syntheses of pyrrolidines and piperidines bearing chiral tertiary alcohols are limited. Here we report… read more here.
Keywords: pyrrolidines piperidines; tertiary alcohols; cyclization; chiral tertiary ... See more keywords
Recent advances in the synthesis of chiral α-tertiary amines via transition-metal catalysis.
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DOI: 10.1039/d3cc00439b
Abstract: The significance of chiral α-tertiary amines in medicinal chemistry and drug development has been unquestionably established in the last few decades. α-Tertiary amines are attractive structural motifs for natural products, bioactive molecules and pharmaceuticals and… read more here.
Keywords: metal catalysis; chemistry; tertiary amines; transition metal ... See more keywords