Synthesis of Chiral Tetrahydro-3-benzazepine Motifs by Iridium-Catalyzed Asymmetric Hydrogenation of Cyclic Ene-carbamates
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DOI: 10.1021/acs.orglett.2c00362
Abstract: A highly efficient N,P-ligated iridium complex is presented for the simple preparation of chiral tetrahydro-3-benzazepine motifs by catalytic asymmetric hydrogenation. Substrates bearing both 1-aryl and 1-alkyl substituents were smoothly converted to the corresponding hydrogenated product… read more here.
Keywords: hydrogenation; chiral tetrahydro; tetrahydro benzazepine; asymmetric hydrogenation ... See more keywords