Concise syntheses and some biological activities of dl‐2,5‐di‐O‐methyl‐chiro‐inositol, dl‐1,4‐di‐O‐methyl‐scyllo‐inositol, and dl‐1,6‐dibromo‐1,6‐dideoxy‐2,5‐di‐O‐methyl‐chiro‐inositol
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DOI: 10.1002/ardp.202000254
Abstract: The regio‐ and stereospecific synthesis of O‐methyl‐chiro‐inositols and O‐methyl‐scyllo‐inositol was achieved, starting from p‐benzoquinone. After preparing dimethoxy conduritol‐B as a key compound, regiospecific bromination of the alkene moiety of dimethoxy conduritol‐B and acid‐catalyzed ring opening… read more here.
Keywords: methyl chiro; inositol; chiro; chiro inositol ... See more keywords
Regio- and stereospecific synthesis of dl-4,5-dibromo-4,5-dideoxy-3,6-O-methyl-chiro-inositol
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DOI: 10.1016/j.tetlet.2018.02.050
Abstract: Abstract The regio- and stereospecific synthesis of dl -4,5-dibromo-4,5-dideoxy-3,6-O-methyl-chiro-inositol is reported. Bromination of p-benzoquinone followed by reduction of the carbonyl groups with NaBH4 gave the corresponding trans-dibromodiol compound, which was reacted with sodium methoxide to… read more here.
Keywords: stereospecific synthesis; dibromo dideoxy; synthesis dibromo; dideoxy methyl ... See more keywords
d-chiro-Inositol Derivatives with Multidrug Resistance Reversal Activities from the Fruits of Chisocheton siamensis.
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DOI: 10.1021/acs.jnatprod.2c01033
Abstract: Chisosiamols A-K (1-11), 11 new d-chiro-inositol derivatives, along with a known analogue (12) were isolated from the fruits of Chisocheton siamensis. Their planar structures and relative configurations were elucidated by the comprehensive application of spectroscopic… read more here.
Keywords: chisocheton siamensis; chiro inositol; multidrug resistance; fruits chisocheton ... See more keywords
D-Chiro-inositol and PCOS: between myth and reality. The never-ending story
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DOI: 10.1080/09637486.2022.2029830
Abstract: Abstract Polycystic ovary syndrome (PCOS) is one of the most common disorders among women of reproductive age and can be diagnosed when at least two of the following criteria are present: chronic ovulatory disorder, clinical… read more here.
Keywords: inositol; inositol pcos; chiro inositol; pcos myth ... See more keywords
POTENTIAL ROLE OF D-CHIRO-INOSITOL IN REDUCING OF OXIDATIVE STRESS IN BLOOD OF NON-OBESE WOMEN WITH POLYCYSTIC OVARY SYNDROME.
Sign Up to like & getrecommendations! Published in 2022 at "Canadian journal of physiology and pharmacology"
DOI: 10.1139/cjpp-2021-0766
Abstract: OBJECTIVE D-chiro inositol (DCI), an isomer of inositol, possesses anti-oxidative and endothelial protective properties. Possibly due to a deficiency of insulin mediators, polycystic ovary syndrome (PCOS) is often associated with insulin resistance (IR) and… read more here.
Keywords: stress; chiro inositol; oxidative stress; polycystic ovary ... See more keywords
The effect of D-chiro-inositol on renal protection in diabetic mice.
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DOI: 10.18632/aging.204019
Abstract: D-Chiro-inositol (DCI) exerts a hypoglycaemic effect, participates in lipid metabolism and reduces kidney damage. In this study, we preliminarily explored the protective effect of DCI on renal injury in diabetic mice. Male db/db mice were… read more here.
Keywords: effect; chiro inositol; diabetic mice; expression ... See more keywords
From Myo-inositol to D-chiro-inositol molecular pathways.
Sign Up to like & getrecommendations! Published in 2021 at "European review for medical and pharmacological sciences"
DOI: 10.26355/eurrev_202103_25279
Abstract: OBJECTIVE Inositol is a carbocyclic sugar polyalcohol. By epimerization of its hydroxyl groups, nine possible stereoisomers can be generated, two of major physiological and clinical relevance: myo-inositol and D-chiro-inositol. Myo-inositol and D-chiro-inositol are normally stored… read more here.
Keywords: myo inositol; inositol; inositol chiro; chiro inositol ... See more keywords
The Improvement Effect of D-Chiro-Inositol and Ecklonia cava K. in the Rat Model of Polycystic Ovarian Syndrome
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DOI: 10.3389/fphar.2022.905191
Abstract: Introduction: Polycystic Ovarian Syndrome (PCOS) is known to be an endocrine state that is characterized by oligomenorrhea, hyperandrogenism, and highly cystic follicles in the ovaries. The use of food ingredients and traditional medicine in Asian… read more here.
Keywords: chiro inositol; ovarian syndrome; ecklonia cava; pcos ... See more keywords
Myo-Inositol and D-Chiro-Inositol as Modulators of Ovary Steroidogenesis: A Narrative Review
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DOI: 10.3390/nu15081875
Abstract: Myo-inositol is a natural polyol, the most abundant among the nine possible structural isomers available in living organisms. Inositol confers some distinctive traits that allow for a striking distinction between prokaryotes and eukaryotes, the basic… read more here.
Keywords: inositol; chiro inositol; inositol chiro; myo inositol ... See more keywords
Metabolic and hormonal effects of a combined Myo-inositol and d-chiro-inositol therapy on patients with polycystic ovary syndrome (PCOS).
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DOI: 10.5603/gp.2019.0002
Abstract: OBJECTIVES To evaluate the effects of a combined Myo-inositol (MI) and D-chiro-inositol (DCI) therapy on the hormonal and metabolic parameters of women with PCOS. Prospective clinical study. Clinical Study registration number - EUPAS25705 Material and… read more here.
Keywords: chiro inositol; therapy; inositol; myo inositol ... See more keywords