Comparative functional analysis between human and mouse chitotriosidase: Substitution at amino acid 218 modulates the chitinolytic and transglycosylation activity.
Sign Up to like & getrecommendations! Published in 2020 at "International journal of biological macromolecules"
DOI: 10.1016/j.ijbiomac.2020.08.173
Abstract: Chitotriosidase (Chit1) and acidic mammalian chitinase (AMCase) have been attracting research interest due to their involvement in various pathological conditions such as Gaucher's disease and asthma, respectively. Both enzymes are highly expressed in mice, while… read more here.
Keywords: chitinolytic transglycosylation; chit1; substitution; amcase ... See more keywords
Influence of chitotriosidase gene polymorphisms on oxidative stress and susceptibility to Aspergillus infection among exposed workers.
Sign Up to like & getrecommendations! Published in 2022 at "International journal of environmental health research"
DOI: 10.1080/09603123.2022.2080189
Abstract: Chitotriosidase (CHIT1) is involved in the innate defense against chitin-containing pathogens. In the present study, we sought to investigate the role of CHIT1 gene polymorphisms on susceptibility to Aspergillus infection in addition to oxidative stress… read more here.
Keywords: susceptibility aspergillus; gene polymorphisms; chit1; infection ... See more keywords
Pharmacological Inhibition of Chitotriosidase (CHIT1) as a Novel Therapeutic Approach for Sarcoidosis
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DOI: 10.2147/jir.s378357
Abstract: Introduction Sarcoidosis is a systemic disease of unknown etiology characterized by granuloma formation in the affected tissues. The pathologically activated macrophages are causatively implicated in disease pathogenesis and play important role in granuloma formation. Chitotriosidase… read more here.
Keywords: sarcoidosis; inflammation; inhibition; chit1 ... See more keywords
Longitudinal and Comparative Measures of Serum Chitotriosidase and YKL-40 in Patients With Idiopathic Pulmonary Fibrosis
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DOI: 10.3389/fimmu.2022.760776
Abstract: Background Although chitin is absent in humans, chitinases are present in healthy subjects and show dysregulated expression in a variety of diseases resulting from abnormal tissue injury and repair responses. It was shown that chitotriosidase… read more here.
Keywords: ykl; serum chit1; chit1 activity; chit1 ... See more keywords
Inhibition of Macrophage-Specific CHIT1 as an Approach to Treat Airway Remodeling in Severe Asthma
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DOI: 10.3390/ijms24054719
Abstract: Chitotriosidase (CHIT1) is an enzyme produced by macrophages that regulates their differentiation and polarization. Lung macrophages have been implicated in asthma development; therefore, we asked whether pharmacological inhibition of macrophage-specific CHIT1 would have beneficial effects… read more here.
Keywords: chit1; macrophage specific; airway remodeling; inhibition macrophage ... See more keywords