Rational Design of N-Methylcarbamoylguanidinyl Derivatives as Highly Potent Dual-Target Chitin Hydrolase Inhibitors for Retarding Growth of Pest Insects.
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DOI: 10.1021/acs.jafc.2c07605
Abstract: Chitin degradation is a vital process for the growth of insects. Chitin hydrolase OfChtI and β-N-acetylhexosaminidase OfHex1 are two key enzymes involved in hydrolyzing the chitin of insects' cuticles. Thus, they are considered promising targets… read more here.
Keywords: chitin; growth; insects; dual target ... See more keywords