Differential expression of Chitinase 3‐Like 1 protein in appendicitis and appendix carcinomas
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Clinical Laboratory Analysis"
DOI: 10.1002/jcla.24790
Abstract: Chitinase 3‐Like 1 (CHI3L1) has been used as an inflammatory biomarker for a variety of diseases, but its expression in acute appendicitis and appendix carcinomas remains unclear. read more here.
Keywords: chitinase like; appendicitis appendix; appendix carcinomas;
Irreversible evolutionary loss of chitin‐degrading ability in the chitinase‐like protein Ym1 under positive selection in rodents
Sign Up to like & getrecommendations! Published in 2023 at "Protein Science"
DOI: 10.1002/pro.4620
Abstract: Ym1 (chitinase‐like 3, Chil3) expressed in mice is a nonenzymatic chitinase‐like protein, which shows 67% identity with mouse acidic chitinase (Chia). Similar to Chia, Ym1 is overexpressed in asthma and parasitic infections in mouse lungs.… read more here.
Keywords: ym1; chitinase like; chitinase; loss ... See more keywords
Chitinase 3-like 1 is associated with the response to interferon-beta treatment in multiple sclerosis
Sign Up to like & getrecommendations! Published in 2017 at "Journal of Neuroimmunology"
DOI: 10.1016/j.jneuroim.2016.12.006
Abstract: Chitinase 3-like 1 (CHI3L1) plays a prognostic role in patients with multiple sclerosis (MS). Here, we investigated a potential association between CHI3L1 and the response to interferon-beta (IFNβ) and glatiramer acetate (GA). Serum CHI3L1 levels… read more here.
Keywords: chitinase like; response; interferon beta; chi3l1 ... See more keywords
Chitinase-like proteins as regulators of innate immunity and tissue repair: helpful lessons for asthma?
Sign Up to like & getrecommendations! Published in 2018 at "Biochemical Society transactions"
DOI: 10.1042/bst20170108
Abstract: Chitinases and chitinase-like proteins (CLPs) belong to the glycoside hydrolase family 18 of proteins. Chitinases are expressed in mammals and lower organisms, facilitate chitin degradation, and hence act as host-defence enzymes. Gene duplication and loss-of-function… read more here.
Keywords: like proteins; chitinase like; tissue; proteins regulators ... See more keywords
Characterization of Chitinase 3-like protein 1 spatiotemporal distribution in human post-traumatic brain contusions and other neuropathological scenarios.
Sign Up to like & getrecommendations! Published in 2025 at "Journal of neuropathology and experimental neurology"
DOI: 10.1093/jnen/nlaf002
Abstract: Chitinase 3-like protein 1 (CHI3L1) is emerging as a promising biomarker for assessing intracranial lesion burden and predicting prognosis in traumatic brain injury (TBI) patients. Following experimental TBI, Chi3l1 transcripts were detected in reactive astrocytes… read more here.
Keywords: traumatic brain; brain; like protein; chitinase like ... See more keywords
PERSISTENT EXPRESSION OF CHITINASE 3-LIKE 1 IN EX VIVO-MAINTAINED GLIOBLASTOMA BIOPSIES DESPITE CHEMOTHERAPY: IMPLICATIONS FOR IMMUNE EVASION
Sign Up to like & getrecommendations! Published in 2025 at "Neuro-Oncology"
DOI: 10.1093/neuonc/noaf185.075
Abstract: Background: Glioblastoma (GBM) remains a highly aggressive and treatment-resistant brain tumour, characterized by pro- found immune suppression. Chitinase 3-like 1 (CHI3L1), a cytokine implicated in tumour progression and im- mune modulation, has been associated with… read more here.
Keywords: persistent expression; expression chitinase; chitinase like; chi3l1 ... See more keywords
Chitinase‐3‐like protein 1 is an independent risk factor for the early failure of forearm autologous arteriovenous fistulas in uremic patients
Sign Up to like & getrecommendations! Published in 2021 at "Therapeutic Apheresis and Dialysis"
DOI: 10.1111/1744-9987.13623
Abstract: Chitinase‐3‐like protein 1 (CHI3L1) has been introduced as a marker of inflammation in different diseases, which can promote cell proliferation and differentiation. It has also been demonstrated that elevated serum CHI3L1 concentration can independently predict… read more here.
Keywords: chitinase like; uremic patients; chi3l1; early failure ... See more keywords
A secreted chitinase-like protein (OsCLP) supports root growth through calcium signaling in Oryza sativa.
Sign Up to like & getrecommendations! Published in 2017 at "Physiologia plantarum"
DOI: 10.1111/ppl.12579
Abstract: Chitinases belong to a conserved protein family and play multiple roles in defense, development and growth regulation in plants. Here, we identified a secreted chitinase-like protein, OsCLP, which functions in rice growth. A T-DNA insertion… read more here.
Keywords: chitinase like; osclp; like protein; secreted chitinase ... See more keywords
Diagnostic Value of Serum Chitinase-3-Like Protein 1 for Liver Fibrosis: A Meta-analysis
Sign Up to like & getrecommendations! Published in 2022 at "BioMed Research International"
DOI: 10.1155/2022/3227957
Abstract: Background Serum chitinase-3-like protein 1 (CHI3L1) is a promising marker for diagnosing liver fibrosis. This meta-analysis was carried out to assess the diagnostic performance of serum CHI3L1 for the estimation of liver fibrosis. Methods Systematic… read more here.
Keywords: chitinase like; liver fibrosis; serum chitinase; analysis ... See more keywords
Chitinase 3-like-1 is a therapeutic target that mediates the effects of aging in COVID-19.
Sign Up to like & getrecommendations! Published in 2021 at "JCI insight"
DOI: 10.1172/jci.insight.148749
Abstract: COVID-19 is caused by SARS-CoV-2 (SC2) and is more prevalent and severe in elderly and patients with comorbid diseases (CM). Because chitinase 3-like-1 (CHI3L1) is induced during aging and CM, the relationships between CHI3L1 and… read more here.
Keywords: effects aging; chi3l1; chitinase like; therapeutic target ... See more keywords
Chitinase 3 like 1 contributes to the development of pulmonary vascular remodeling in pulmonary hypertension
Sign Up to like & getrecommendations! Published in 2022 at "JCI Insight"
DOI: 10.1172/jci.insight.159578
Abstract: Chitinase 3 like 1 (CHI3L1) is the prototypic chitinase-like protein mediating inflammation, cell proliferation, and tissue remodeling. Limited data suggest CHI3L1 is elevated in human pulmonary arterial hypertension (PAH) and is associated with disease severity.… read more here.
Keywords: chitinase like; hypertension; vascular remodeling; pulmonary vascular ... See more keywords