Choline kinase alpha 2 acts as a protein kinase to promote lipolysis of lipid droplets.
Sign Up to like & getrecommendations! Published in 2021 at "Molecular cell"
DOI: 10.1016/j.molcel.2021.05.005
Abstract: Lipid droplets are important for cancer cell growth and survival. However, the mechanism underlying the initiation of lipid droplet lipolysis is not well understood. We demonstrate here that glucose deprivation induces the binding of choline… read more here.
Keywords: choline kinase; chk; lipid droplets; lipolysis ... See more keywords
The moonlighting function of glycolytic enzyme enolase-1 promotes choline phospholipid metabolism and tumor cell proliferation.
Sign Up to like & getrecommendations! Published in 2023 at "Proceedings of the National Academy of Sciences of the United States of America"
DOI: 10.1073/pnas.2209435120
Abstract: Aberrantly upregulated choline phospholipid metabolism is a novel emerging hallmark of cancer, and choline kinase α (CHKα), a key enzyme for phosphatidylcholine production, is overexpressed in many types of human cancer through undefined mechanisms. Here,… read more here.
Keywords: choline phospholipid; metabolism; phospholipid metabolism; glycolytic enzyme ... See more keywords
Abstract 1680: The immune checkpoint metabolome and its relationship with choline metabolism
Sign Up to like & getrecommendations! Published in 2018 at "Immunology"
DOI: 10.1158/1538-7445.am2018-1680
Abstract: Introduction: Immune checkpoint inhibition has emerged as an exciting treatment option for several cancers. New insights into the role of immune checkpoints in cellular metabolism can be used to optimize their effectiveness in treatment. Programmed… read more here.
Keywords: immune checkpoint; chk; choline metabolism; checkpoint ... See more keywords
Regulation, targets and functions of CHK
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Cell and Developmental Biology"
DOI: 10.3389/fcell.2022.1068952
Abstract: Src family kinases (SFKs) play pivotal roles in multiple signaling pathways (Yeatman, 2004). SFK activity is inhibited by phosphorylation at its C-terminal tyrosine, by CSK (C-terminal Src kinase) and CHK (CSK-homologous kinase). CHK expression is… read more here.
Keywords: functions chk; regulation targets; kinase; targets functions ... See more keywords