The miR-34a-5p-c-MYC-CHK1/CHK2 Axis Counteracts Cancer Stem Cell-Like Properties and Enhances Radiosensitivity in Hepatocellular Cancer Through Repression of the DNA Damage Response
Sign Up to like & getrecommendations! Published in 2022 at "Radiation Research"
DOI: 10.1667/rade-22-00098.1
Abstract: Radiotherapy has become an increasingly widespread modality for treating hepatocellular cancer (HCC); however, the development of radioresistance significantly limits its effectiveness and invariably leads to tumor recurrence. Cancer stem cell (CSC) theory offers a potential… read more here.
Keywords: radiosensitivity; cancer; dna damage; hcc ... See more keywords
53BP1 regulates cell cycle arrest in esophageal cancer model.
Sign Up to like & getrecommendations! Published in 2019 at "European review for medical and pharmacological sciences"
DOI: 10.26355/eurrev_201901_16874
Abstract: OBJECTIVE This study aims to investigate effects of checkpoint kinase, mediator of DNA damage checkpoint 1 (MDC1) and p53-binding protein 1 (53BP1) silencing on p53, checkpoint kinase 1 and 2 (CHK1 and CHK2), and CHK2-T68… read more here.
Keywords: chk1 chk2; group; chk2; expression ... See more keywords