Induction of protection in mice against a respiratory challenge by a vaccine formulated with exosomes isolated from Chlamydia muridarum infected cells
Sign Up to like & getrecommendations! Published in 2020 at "NPJ Vaccines"
DOI: 10.1038/s41541-020-00235-x
Abstract: The goal of this study was to determine if exosomes, isolated from Chlamydia muridarum infected HeLa cells (C. muridarum-exosomes), induce protective immune responses in mice following vaccination using CpG plus Montanide as adjuvants. Exosomes, collected… read more here.
Keywords: isolated chlamydia; muridarum; exosomes isolated; chlamydia muridarum ... See more keywords
GlgA plays an important role in the induction of hydrosalpinx by chlamydia muridarum.
Sign Up to like & getrecommendations! Published in 2020 at "Pathogens and disease"
DOI: 10.1093/femspd/ftaa027
Abstract: While glycogen synthase A deficiency can reduce the growth and proliferation of Chlamydia muridarum, the effect of glycogen synthase A on the pathogenic process of Chlamydia muridarum remains unclear. To characterize the effect of glycogen… read more here.
Keywords: muridarum; glycogen synthase; chlamydia muridarum;
A primary study on genes with selected mutations by in vitro passage of Chlamydia muridarum strains.
Sign Up to like & getrecommendations! Published in 2019 at "Pathogens and disease"
DOI: 10.1093/femspd/ftz017
Abstract: OBJECTIVE This study is to investigate the functions of newly discovered genes in Chlamydia muridarum (C. muridarum) strains with single gene differences. METHODS Using whole genome sequencing and plaque formation assays, C. muridarum parental and… read more here.
Keywords: muridarum strains; muridarum; study; chlamydia muridarum ... See more keywords
Adoptive Transfer of Group 3-Like Innate Lymphoid Cells Restores Mouse Colon Resistance to Colonization of a Gamma Interferon-Susceptible Chlamydia muridarum Mutant
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DOI: 10.1128/iai.00533-20
Abstract: The obligate intracellular bacterium Chlamydia muridarum can colonize the mouse colon for a long period, but a gamma interferon (IFN-γ)-susceptible mutant clone fails to do so. Nevertheless, the mutant’s colonization is rescued in mice deficient… read more here.
Keywords: chlamydia muridarum; ilcs; mice; colonization ... See more keywords
Chlamydia muridarum Infection of Macrophages Stimulates IL-1β Secretion and Cell Death via Activation of Caspase-1 in an RIP3-Independent Manner
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DOI: 10.1155/2017/1592365
Abstract: Chlamydiae are Gram-negative bacteria, which replicate exclusively in the infected host cells. Infection of the host cells by Chlamydiae stimulates the innate immune system leading to an inflammatory response, which is manifested not only by… read more here.
Keywords: caspase; rip3; infection; chlamydia muridarum ... See more keywords
Reemergence of the Murine Bacterial Pathogen Chlamydia muridarum in Research Mouse Colonies.
Sign Up to like & getrecommendations! Published in 2022 at "Comparative medicine"
DOI: 10.30802/aalas-cm-22-000045
Abstract: Chlamydia muridarum (Cm) was detected in 2 colonies of mice with lymphoplasmacytic pulmonary infiltrates by using PCR and immunohistochemistry. This discovery was unexpected, as Cm infection had not been reported in laboratory mice since the… read more here.
Keywords: academic institutions; chlamydia muridarum; mouse colonies; mouse ... See more keywords
Modulation of Immune Response to Chlamydia muridarum by Host miR-135a
Sign Up to like & getrecommendations! Published in 2021 at "Frontiers in Cellular and Infection Microbiology"
DOI: 10.3389/fcimb.2021.638058
Abstract: Previously, our laboratory established the role of small, noncoding RNA species, i.e., microRNA (miRNA) including miR-135a in anti-chlamydial immunity in infected hosts. We report here chlamydial infection results in decreased miR-135a expression in mouse genital… read more here.
Keywords: mir; infection; chlamydia muridarum; mir 135a ... See more keywords