Chlorambucil combination therapy in refractory serpiginous choroiditis: A cure?
Sign Up to like & getrecommendations! Published in 2021 at "American Journal of Ophthalmology Case Reports"
DOI: 10.1016/j.ajoc.2021.101014
Abstract: Purpose To find a remedy for serpiginous choroiditis refractory to oral prednisone and chlorambucil treatment. Observations Eight eyes of four patients (all female) with advanced macular involvement secondary to serpiginous choroiditis were included in the… read more here.
Keywords: combination; serpiginous choroiditis; chlorambucil; case ... See more keywords
Chlorambucil-conjugated platinum(IV) prodrugs to treat triple-negative breast cancer in vitro and in vivo.
Sign Up to like & getrecommendations! Published in 2018 at "European journal of medicinal chemistry"
DOI: 10.1016/j.ejmech.2018.08.065
Abstract: Modification of platinum (II) into lipophilic platinum (IV) compounds by introducing biologically active molecules were widely employed to develop new platinum-based prodrugs in the past decade. In this paper, two chlorambucil platinum (IV) complexes, CLB-Pt… read more here.
Keywords: clb clb; platinum; chlorambucil; clb ... See more keywords
Temperature‐responsive voltammetric sensor based on stimuli-sensitive semi-interpenetrating polymer network conductive microgels for reversible switch detection of nitrogen mustard analog chlorambucil (Leukeran™)
Sign Up to like & getrecommendations! Published in 2021 at "Electrochimica Acta"
DOI: 10.1016/j.electacta.2021.137866
Abstract: Abstract In this study, we report the synthesis of thermosensitive poly(N-vinylcaprolactam) semi-interpenetrated conductive polypyrrole microgels (PVCL/PPY semi-IPN MGs) for “on-off” switchable electrochemical sensing of carcinogenic nitrogen mustard drug chlorambucil (Leukeran™). The synthesized PVCL/PPY semi-IPN MGs… read more here.
Keywords: semi; chlorambucil; pvcl ppy; temperature ... See more keywords
Canine (Pet Dog) Tumor Microsurgery and Intratumoral Concentration and Safety of Metronomic Chlorambucil for Spontaneous Glioma: A Phase I Clinical Trial.
Sign Up to like & getrecommendations! Published in 2018 at "World neurosurgery"
DOI: 10.1016/j.wneu.2018.05.027
Abstract: OBJECTIVE Metronomic (daily low-dose) chlorambucil requires further study before use in human patients with glioma. The aim of this study was to investigate distribution and safety of metronomic chlorambucil in naturally occurring canine glioma. METHODS… read more here.
Keywords: glioma; canine; safety; chlorambucil ... See more keywords
Dual approach: micellar delivery of chlorambucil prodrug with concurrent glutathione depletion and GST inhibition for enhanced anticancer activity
Sign Up to like & getrecommendations! Published in 2024 at "Nanotechnology"
DOI: 10.1088/1361-6528/ad501a
Abstract: Although chlorambucil (CHL) is a long-established anticancer drug, the drug failure of CHL, mediated by the intracellular defense system consisting of glutathione (GSH) and GSH S-transferase pi (GST-pi), has significantly limited the application of CHL.… read more here.
Keywords: glutathione; gst; depletion; chlorambucil ... See more keywords
Chlorambucil Cytotoxicity Reduction in Rats Through Bone Marrow, An In vivo Study.
Sign Up to like & getrecommendations! Published in 2018 at "Anti-cancer agents in medicinal chemistry"
DOI: 10.2174/1871520618666180907170317
Abstract: BACKGROUND Bone Marrow (BM) has the self-renovation capacity and has been used recently in tumor medicine. Chlorambucil [CHB] is ordinarily utilized chemotherapy to treat varieties of malignancy patients. This investigation intended to gauge the effectiveness… read more here.
Keywords: vivo; mitotic index; study; chlorambucil ... See more keywords
A cross-trial comparison of single-agent ibrutinib versus chlorambucil-obinutuzumab in previously untreated patients with chronic lymphocytic leukemia or small lymphocytic lymphoma
Sign Up to like & getrecommendations! Published in 2019 at "Haematologica"
DOI: 10.3324/haematol.2019.223743
Abstract: The treatment landscape for patients with chronic lymphocytic leukemia/small lymphocytic lymphoma (CLL/SLL) has evolved from single-agent/combination chemotherapies to anti-CD20 antibody-containing regimens, including chemoimmunotherapy, to novel agents targeting the B-cell receptor signaling pathway or BCL2. In… read more here.
Keywords: single agent; ibrutinib; agent ibrutinib; analysis ... See more keywords
Discovery of a potent olaparib–chlorambucil hybrid inhibitor of PARP1 for the treatment of cancer
Sign Up to like & getrecommendations! Published in 2023 at "Frontiers in Pharmacology"
DOI: 10.3389/fphar.2022.1054616
Abstract: Introduction: Development of Poly (ADP-ribose) polymerase (PARP) inhibitors has been extensively studied in cancer treatment. Olaparib, the first approved PARP inhibitor, showed potency in the inhibition of both BRCA (breast cancer associated)-mutated and BRCA-unmutated cancers.… read more here.
Keywords: chlorambucil; cancer; olaparib chlorambucil; treatment cancer ... See more keywords
Obinutuzumab in Combination with Alternative Chlorambucil Schedules in Front-Line Treatment of Chronic Lymphocytic Leukemia: A Study by KroHem, the Croatian Cooperative Group for Hematologic Diseases
Sign Up to like & getrecommendations! Published in 2024 at "Biomedicines"
DOI: 10.3390/biomedicines12122902
Abstract: Background/Objectives: Obinutuzumab was approved for front-line treatment of chronic lymphocytic leukemia in combination with chlorambucil pulses administered every 2 wks. Alternative schedules of chlorambucil enable the administration of higher total chlorambucil doses, and have better… read more here.
Keywords: combination; chlorambucil schedules; chronic lymphocytic; chlorambucil ... See more keywords
Combination Chlorambucil/Firocoxib or Chlorambucil/Prednisolone Treatment for Inflammatory Colorectal Polyps in Miniature Dachshunds.
Sign Up to like & getrecommendations! Published in 2018 at "Journal of the American Animal Hospital Association"
DOI: 10.5326/jaaha-ms-6663
Abstract: Inflammatory colorectal polyps (ICRP), which are more commonly recognized in miniature dachshunds, are thought to represent an immune-mediated disease. This retrospective case series describes six miniature dachshunds with refractory ICRP, who were treated with chlorambucil… read more here.
Keywords: treatment; miniature dachshunds; chlorambucil; inflammatory colorectal ... See more keywords