ClC‐3 chloride channels are involved in estradiol regulation of bone formation by MC3T3‐E1 osteoblasts
Sign Up to like & getrecommendations! Published in 2018 at "Journal of Cellular Biochemistry"
DOI: 10.1002/jcb.28121
Abstract: Evidence has been reported by us and others supporting the important roles of chloride channels in a number of osteoblast cell functions. The ClC‐3 chloride channel is activated by estradiol binding to estrogen receptor alpha… read more here.
Keywords: bone formation; clc chloride; chloride channel; chloride channels ... See more keywords
The Mechanistic Role of the Calcium-Activated Chloride Channel ANO1 in Tumor Growth and Signaling.
Sign Up to like & getrecommendations! Published in 2017 at "Advances in experimental medicine and biology"
DOI: 10.1007/5584_2016_201
Abstract: Multiple studies have described the high expression and amplification of Anoctamin 1 (ANO1) in various cancers, including, but not limited to breast cancer, head and neck cancer, gastrointestinal stromal tumors and glioblastoma. ANO1 has been… read more here.
Keywords: chloride channel; calcium activated; cancer; ano1 ... See more keywords
Substituted 2-Acylaminocycloalkylthiophene-3-carboxylic Acid Arylamides as Inhibitors of the Calcium-Activated Chloride Channel Transmembrane Protein 16A (TMEM16A).
Sign Up to like & getrecommendations! Published in 2017 at "Journal of medicinal chemistry"
DOI: 10.1021/acs.jmedchem.7b00020
Abstract: Transmembrane protein 16A (TMEM16A), also called anoctamin 1 (ANO1), is a calcium-activated chloride channel expressed widely mammalian cells, including epithelia, vascular smooth muscle tissue, electrically excitable cells, and some tumors. TMEM16A inhibitors have been proposed… read more here.
Keywords: protein 16a; chloride channel; activated chloride; calcium activated ... See more keywords
Supramolecular nanoprodrug based on a chloride channel blocker and glycosylated pillar[5]arenes for targeted chemoresistance cancer therapy.
Sign Up to like & getrecommendations! Published in 2023 at "Chemical communications"
DOI: 10.1039/d3cc00233k
Abstract: A supramolecular nanoprodrug (DOX@GP5⊃Pro-NFA) was constructed based on the host-guest complexation of chloride channel blocker prodrug (Pro-NFA) and glycosylated pillar[5]arene (GP5), which could target tumor cells via galactose and release DOX/NFA responsively under esterase stimulation.… read more here.
Keywords: supramolecular nanoprodrug; channel blocker; chloride channel; glycosylated pillar ... See more keywords
Development and validation of a potent and specific inhibitor for the CLC-2 chloride channel.
Sign Up to like & getrecommendations! Published in 2020 at "Proceedings of the National Academy of Sciences of the United States of America"
DOI: 10.1073/pnas.2009977117
Abstract: CLC-2 is a voltage-gated chloride channel that is widely expressed in mammalian tissues. In the central nervous system, CLC-2 appears in neurons and glia. Studies to define how this channel contributes to normal and pathophysiological… read more here.
Keywords: clc; chloride channel; channel; inhibitor clc ... See more keywords
Bibliometric analysis of chloride channel research (2004–2019)
Sign Up to like & getrecommendations! Published in 2020 at "Channels"
DOI: 10.1080/19336950.2020.1835334
Abstract: In recent years, both cation [1]and anion channels [2,3] have emerged as significant molecules with aberrant expression, activity, and localization in various pathological conditions such as cardiovascular dysfunction, neurological disorders, metabolic diseases, and cancers. The… read more here.
Keywords: research; chloride channel; channel research; chloride channels ... See more keywords
Chloride channel inhibition improves neuromuscular function under conditions mimicking neuromuscular disorders
Sign Up to like & getrecommendations! Published in 2021 at "Acta Physiologica"
DOI: 10.1111/apha.13690
Abstract: The skeletal muscle Cl− channels, the ClC‐1 channels, stabilize the resting membrane potential and dampen muscle fibre excitability. This study explored whether ClC‐1 inhibition can recover nerve‐stimulated force in isolated muscle under conditions of compromised… read more here.
Keywords: inhibition improves; inhibition; channel inhibition; chloride channel ... See more keywords
Gating choreography and mechanism of the human proton-activated chloride channel ASOR
Sign Up to like & getrecommendations! Published in 2022 at "Science Advances"
DOI: 10.1126/sciadv.abm3942
Abstract: The proton-activated chloride channel ASOR (TMEM206/PAC) permeates anions across cellular membranes in response to acidification, thereby enhancing acid-induced cell death and regulating endocytosis. The molecular mechanisms of pH-dependent control are not understood, in part because… read more here.
Keywords: chloride channel; proton activated; asor; activated chloride ... See more keywords
Functional Analysis and Clinical Significance of Chloride Channel 2 Expression in Esophageal Squamous Cell Carcinoma
Sign Up to like & getrecommendations! Published in 2021 at "Annals of Surgical Oncology"
DOI: 10.1245/s10434-021-09659-8
Abstract: Chloride channel 2 (CLCN2) was recently shown to affect tumor behavior. The present study examined the functions of CLCN2 in the regulation of genes that play a role in tumor progression, as well as its… read more here.
Keywords: clcn2; esophageal squamous; analysis; chloride channel ... See more keywords
Attenuation of Hippocampal Evoked Potentials in vivo by Activation of GtACR2, an Optogenetic Chloride Channel
Sign Up to like & getrecommendations! Published in 2021 at "Frontiers in Neuroscience"
DOI: 10.3389/fnins.2021.653844
Abstract: Aim GtACR2, a light-activated chloride channel, is an attractive tool for neural inhibition as it can shunt membrane depolarizations. In this study, we assessed the effect of activating GtACR2 on in vivo hippocampal CA1 activity… read more here.
Keywords: activation gtacr2; light pulse; chloride channel; gtacr2 ... See more keywords
Tadalafil Rescues the p.M325T Mutant of Best1 Chloride Channel
Sign Up to like & getrecommendations! Published in 2023 at "Molecules"
DOI: 10.3390/molecules28083317
Abstract: Bestrophin 1 (Best1) is a chloride channel that localises to the plasma membrane of retinal pigment epithelium (RPE) cells. Mutations in the BEST1 gene are associated with a group of untreatable inherited retinal dystrophies (IRDs)… read more here.
Keywords: mutant best1; chloride channel; m325t mutant; best1 chloride ... See more keywords