Renal Chloride Channels in Relation to Sodium Chloride Transport.
Sign Up to like & getrecommendations! Published in 2018 at "Comprehensive Physiology"
DOI: 10.1002/cphy.c180024
Abstract: The many mechanisms governing NaCl absorption in the diverse parts of the renal tubule have been largely elucidated, although some of them, as neutral NaCl absorption across the cortical collecting duct or regulation through with-no-lysine… read more here.
Keywords: nacl absorption; renal chloride; clc; channels relation ... See more keywords
ClC‐3 chloride channels are involved in estradiol regulation of bone formation by MC3T3‐E1 osteoblasts
Sign Up to like & getrecommendations! Published in 2018 at "Journal of Cellular Biochemistry"
DOI: 10.1002/jcb.28121
Abstract: Evidence has been reported by us and others supporting the important roles of chloride channels in a number of osteoblast cell functions. The ClC‐3 chloride channel is activated by estradiol binding to estrogen receptor alpha… read more here.
Keywords: bone formation; clc chloride; chloride channel; chloride channels ... See more keywords
Characterization of Schistosoma mansoni Glutamate-Gated Chloride Channels.
Sign Up to like & getrecommendations! Published in 2020 at "Methods in molecular biology"
DOI: 10.1007/978-1-0716-0635-3_14
Abstract: Electrophysiology is the standard method for characterizing ion channel function. Two-electrode voltage clamp is a robust and relatively simple version which can be applied to the characterization of glutamate-gated chloride channels from Schistosoma mansoni, a… read more here.
Keywords: gated chloride; glutamate gated; chloride channels; schistosoma mansoni ... See more keywords
Glial Chloride Channels in the Function of the Nervous System Across Species.
Sign Up to like & getrecommendations! Published in 2021 at "Advances in experimental medicine and biology"
DOI: 10.1007/978-981-16-4254-8_10
Abstract: In the nervous system, the concentration of Cl- in neurons that express GABA receptors plays a key role in establishing whether these neurons are excitatory, mostly during early development, or inhibitory. Thus, much attention has… read more here.
Keywords: system; chloride channels; concentration; glial chloride ... See more keywords
Identification and pharmacological characterization of histamine-gated chloride channels in the fall armyworm, Spodoptera frugiperda.
Sign Up to like & getrecommendations! Published in 2021 at "Insect biochemistry and molecular biology"
DOI: 10.1016/j.ibmb.2021.103698
Abstract: Histamine-gated chloride channels (HACls) mediate fast inhibitory neurotransmission in invertebrate nervous systems and have important roles in light reception, color processing, temperature preference and light-dark cycle. The fall armyworm, Spodoptera frugiperda is a main destructive… read more here.
Keywords: chloride channels; frugiperda; histamine gated; fall armyworm ... See more keywords
Bibliometric analysis of chloride channel research (2004–2019)
Sign Up to like & getrecommendations! Published in 2020 at "Channels"
DOI: 10.1080/19336950.2020.1835334
Abstract: In recent years, both cation [1]and anion channels [2,3] have emerged as significant molecules with aberrant expression, activity, and localization in various pathological conditions such as cardiovascular dysfunction, neurological disorders, metabolic diseases, and cancers. The… read more here.
Keywords: research; chloride channel; channel research; chloride channels ... See more keywords
Intracellular Chloride Channels Regulate Endothelial Metabolic Reprogramming in Pulmonary Arterial Hypertension.
Sign Up to like & getrecommendations! Published in 2022 at "American journal of respiratory cell and molecular biology"
DOI: 10.1165/rcmb.2022-0111oc
Abstract: Mitochondrial fission and a metabolic switch from oxidative phosphorylation to glycolysis are key features of vascular pathology in pulmonary arterial hypertension (PAH) and are associated with exuberant endothelial proliferation and apoptosis. The underlying mechanisms are… read more here.
Keywords: arterial hypertension; intracellular chloride; chloride channels; pulmonary arterial ... See more keywords
Tracking of unfamiliar odors is facilitated by signal amplification through anoctamin 2 chloride channels in mouse olfactory receptor neurons
Sign Up to like & getrecommendations! Published in 2017 at "Physiological Reports"
DOI: 10.14814/phy2.13373
Abstract: Many animals follow odor trails to find food, nesting sites, or mates, and they require only faint olfactory cues to do so. The performance of a tracking dog, for instance, poses the question on how… read more here.
Keywords: olfactory receptor; anoctamin chloride; chloride channels; signal amplification ... See more keywords
Mechanisms of Action, Resistance and Toxicity of Insecticides Targeting GABA Receptors.
Sign Up to like & getrecommendations! Published in 2017 at "Current medicinal chemistry"
DOI: 10.2174/0929867324666170613075736
Abstract: BACKGROUND γ-Aminobutyric acid (GABA) receptors play a central role in fast inhibitory neurotransmission in insects. Several classes of insecticides targeting insect GABA-gated chloride channels have been developed. The important resistant to dieldrin GABA receptor subunit… read more here.
Keywords: gaba receptors; gated chloride; insecticides targeting; gaba ... See more keywords
Pharmacological modulation of chloride channels as a therapeutic strategy for neurological disorders
Sign Up to like & getrecommendations! Published in 2023 at "Frontiers in Physiology"
DOI: 10.3389/fphys.2023.1122444
Abstract: Chloride homeostasis is critical in the physiological functions of the central nervous system (CNS). Its concentration is precisely regulated by multiple ion-transporting proteins such as chloride channels and transporters that are widely distributed in the… read more here.
Keywords: channels therapeutic; modulation chloride; neurological disorders; chloride channels ... See more keywords
Small Molecules Targeting Kidney ClC-K Chloride Channels: Applications in Rare Tubulopathies and Common Cardiovascular Diseases
Sign Up to like & getrecommendations! Published in 2023 at "Biomolecules"
DOI: 10.3390/biom13040710
Abstract: Given the key role played by ClC-K chloride channels in kidney and inner ear physiology and pathology, they can be considered important targets for drug discovery. Indeed, ClC-Ka and ClC-Kb inhibition would interfere with the… read more here.
Keywords: clc chloride; chloride channels; clc; molecules targeting ... See more keywords