THE ROLE OF URINARY EXOSOMAL SODIUM CHLORIDE COTRANSPORTER IN SUBTYPING PRIMARY ALDOSTERONISM
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DOI: 10.1097/01.hjh.0000837492.67542.80
Abstract: Objective: Adrenal venous sampling (AVS) is recognized as the gold standard for subtyping primary aldosteronism (PA), but its invasive nature and technical challenges limit its availability. A recent study reported that sodium chloride cotransporter (NCC)… read more here.
Keywords: sodium chloride; subtyping primary; chloride cotransporter; group ... See more keywords
Cryo-EM structure of the human sodium-chloride cotransporter NCC
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DOI: 10.1126/sciadv.add7176
Abstract: The sodium-chloride cotransporter NCC mediates the coupled import of sodium and chloride across the plasma membrane, playing vital roles in kidney extracellular fluid volume and blood pressure control. Here, we present the full-length structure of… read more here.
Keywords: sodium chloride; cotransporter ncc; structure; chloride cotransporter ... See more keywords
Molecular cloning and biochemical characterization of two cation chloride cotransporter subfamily members of Hydra vulgaris
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DOI: 10.1371/journal.pone.0179968
Abstract: Cation Chloride Cotransporters (CCCs) comprise secondary active membrane proteins mainly mediating the symport of cations (Na+, K+) coupled with chloride (Cl−). They are divided into K+-Cl− outward transporters (KCCs), the Na+-K+-Cl− (NKCCs) and Na+-Cl− (NCCs)… read more here.
Keywords: cation chloride; cotransporter; hydra vulgaris; chloride cotransporter ... See more keywords
A Novel View on the Role of Intracellular Tails in Surface Delivery of the Potassium-Chloride Cotransporter KCC2
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DOI: 10.1523/eneuro.0055-17.2017
Abstract: Abstract A plethora of neurological disorders are associated with alterations in the expression and localization of potassium-chloride cotransporter type 2 (KCC2), making KCC2 a critical player in neuronal function and an attractive target for therapeutic… read more here.
Keywords: role intracellular; role; potassium chloride; chloride cotransporter ... See more keywords
In Primary Aldosteronism, Mineralocorticoids Influence Exosomal Sodium-Chloride Cotransporter Abundance.
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DOI: 10.1681/asn.2015111221
Abstract: Distal tubular sodium retention is a potent driver of hypertension, and the thiazide-sensitive sodium-chloride cotransporter (NCC) has a key role in this process. In humans, factors regulating NCC are unclear, but in animal models, aldosterone… read more here.
Keywords: primary aldosteronism; sodium; chloride cotransporter; abundance ... See more keywords