The structural basis of function and regulation of neuronal cotransporters NKCC1 and KCC2
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DOI: 10.1038/s42003-021-01750-w
Abstract: NKCC and KCC transporters mediate coupled transport of Na + +K + +Cl − and K + +Cl − across the plasma membrane, thus regulating cell Cl − concentration and cell volume and playing critical… read more here.
Keywords: structural basis; microscopy; transport; cation chloride ... See more keywords
Cation-Chloride Cotransporters KCC2 and NKCC1 as Therapeutic Targets in Neurological and Neuropsychiatric Disorders
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DOI: 10.3390/molecules28031344
Abstract: Neurological diseases including Alzheimer’s, Huntington’s disease, Parkinson’s disease, Down syndrome and epilepsy, and neuropsychiatric disorders such as schizophrenia, are conditions that affect not only individuals but societies on a global scale. Current therapies offer a… read more here.
Keywords: cation chloride; chloride cotransporters; cotransporters kcc2; neuropsychiatric disorders ... See more keywords