Chloride transporters and channels in β-cell physiology: revisiting a 40-year-old model
Sign Up to like & getrecommendations! Published in 2019 at "Biochemical Society Transactions"
DOI: 10.1042/bst20190513
Abstract: It is accepted that insulin-secreting β-cells release insulin in response to glucose even in the absence of functional ATP-sensitive K+ (KATP)-channels, which play a central role in a ‘consensus model’ of secretion broadly accepted and… read more here.
Keywords: chloride transporters; transporters channels; model; insulin secretion ... See more keywords
Chloride transporters controlling neuronal excitability.
Sign Up to like & getrecommendations! Published in 2022 at "Physiological reviews"
DOI: 10.1152/physrev.00025.2021
Abstract: Synaptic inhibition plays a crucial role in regulating neuronal excitability, which is the foundation of nervous system function. This inhibition is largely mediated by the neurotransmitters GABA and glycine that activate Cl--permeable ion channels, which… read more here.
Keywords: neuronal excitability; controlling neuronal; excitability; transporters controlling ... See more keywords
Dysregulation of GABAergic Signaling in Neurodevelomental Disorders: Targeting Cation-Chloride Co-transporters to Re-establish a Proper E/I Balance
Sign Up to like & getrecommendations! Published in 2021 at "Frontiers in Cellular Neuroscience"
DOI: 10.3389/fncel.2021.813441
Abstract: The construction of the brain relies on a series of well-defined genetically and experience- or activity -dependent mechanisms which allow to adapt to the external environment. Disruption of these processes leads to neurological and psychiatric… read more here.
Keywords: establish proper; cation chloride; cation; chloride transporters ... See more keywords