Enzymatic preparation of optically pure t-butyl 6-chloro-(3R,5S)-dihydroxyhexanoate by a novel alcohol dehydrogenase discovered from Klebsiella oxytoca
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DOI: 10.1016/j.procbio.2017.03.019
Abstract: Abstract Alcohol dehydrogenases can catalyze the inter-conversion of aldehydes and alcohols. The t -butyl 6-chloro-(3 R ,5 S )-dihydroxyhexanoate is a key chiral intermediate in the synthesis of statin-type drugs such as Crestor (rosuvastatin calcium)… read more here.
Keywords: butyl chloro; novel alcohol; chloro dihydroxyhexanoate; alcohol dehydrogenase ... See more keywords