Evaluation of antifungal activity, mechanisms of action and toxicological profile of the synthetic amide 2-chloro-N-phenylacetamide.
Sign Up to like & getrecommendations! Published in 2023 at "Drug and chemical toxicology"
DOI: 10.1080/01480545.2022.2158849
Abstract: Aspergillus niger causes infections such as otitis and pulmonary aspergillosis in immunocompromised individuals. Treatment involves voriconazole or amphotericin B, and due to the increase in fungal resistance, the search for new compounds with antifungal activity… read more here.
Keywords: antifungal activity; action; chloro; chloro phenylacetamide ... See more keywords
Antifungal activity of 2-Chloro-N-phenylacetamide, docking and molecular dynamics studies against clinical isolates of Candida tropicalis and Candida parapsilosis.
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DOI: 10.1111/jam.15498
Abstract: AIMS This study evaluated the antifungal, antibiofilm, and molecular docking of 2-Chloro-N-phenylacetamide against clinical isolates of Candida tropicalis and Candida parapsilosis. METHODS AND RESULTS MIC of the test drugs was determined by microdilution. A1Cl obtained… read more here.
Keywords: a1cl; parapsilosis; isolates candida; activity ... See more keywords
Antifungal activity and mechanism of action of 2-chloro-N -phenylacetamide: a new molecule with activity against strains of Aspergillus flavus.
Sign Up to like & getrecommendations! Published in 2021 at "Anais da Academia Brasileira de Ciencias"
DOI: 10.1590/0001-3765202120200997
Abstract: Aspergillus genus causes many diseases, and the species Aspergillus flavus is highly virulent. Treatment of aspergillosis involves azole derivatives such as voriconazole and polyenes such as amphotericin B. Due to an increase in fungal resistance,… read more here.
Keywords: antifungal activity; mechanism action; activity; aspergillus flavus ... See more keywords