Target Identification Using Cell Permeable and Cleavable Chloroalkane Derivatized Small Molecules.
Sign Up to like & getrecommendations! Published in 2017 at "Methods in molecular biology"
DOI: 10.1007/978-1-4939-7201-2_6
Abstract: An important aspect for gaining functional insight into the activity of small molecules revealed through phenotypic screening is the identification of their interacting proteins. Yet, isolating and validating these interacting proteins remains difficult. Here, we… read more here.
Keywords: chloroalkane; small molecules; target identification; cell ... See more keywords
Streamlined Target Deconvolution Approach Utilizing a Single Photoreactive Chloroalkane Capture Tag.
Sign Up to like & getrecommendations! Published in 2021 at "ACS chemical biology"
DOI: 10.1021/acschembio.0c00987
Abstract: Identification of physiologically relevant targets for lead compounds emerging from drug discovery screens is often the rate-limiting step toward understanding their mechanism of action and potential for undesired off-target effects. To this end, we developed… read more here.
Keywords: chloroalkane; approach utilizing; tag; capture ... See more keywords