Potential negative effects of the free use of chloroquine to manage COVID‐19 in Colombia
Sign Up to like & getrecommendations! Published in 2020 at "Journal of Medical Virology"
DOI: 10.1002/jmv.26059
Abstract: Coronavirus disease 2019 (COVID-19) pandemic has challenged healthcare systems around the world. Unfortunately, failure has ensued: high-income countries have succumbed to the global emergency despite highly prepared human and technological assets. There is no current… read more here.
Keywords: effects free; use; covid; chloroquine ... See more keywords
Chloroquine blocks the Kir4.1 channels by an open‐pore blocking mechanism
Sign Up to like & getrecommendations! Published in 2017 at "European Journal of Pharmacology"
DOI: 10.1016/j.ejphar.2017.02.024
Abstract: ABSTRACT Kir4.1 channels have been implicated in various physiological processes, mainly in the K+ homeostasis of the central nervous system and in the control of glial function and neuronal excitability. Even though, pharmacological research of… read more here.
Keywords: blocks kir4; mechanism; pharmacology; chloroquine ... See more keywords
Low dosage chloroquine protects retinal ganglion cells against glutamate‐induced cell death
Sign Up to like & getrecommendations! Published in 2019 at "Experimental Eye Research"
DOI: 10.1016/j.exer.2019.02.022
Abstract: HIGHLIGHTSChloroquine at a low dosage protects RGCs against death and apoptosis.Chloroquine activates anti‐apoptosis genes and reversing apoptotic proteins.An in vivo protective role of chloroquine was demonstrated. read more here.
Keywords: death; chloroquine protects; dosage chloroquine; chloroquine ... See more keywords
Chloroquine kills hair cells in zebrafish lateral line and murine cochlear cultures: Implications for ototoxicity
Sign Up to like & getrecommendations! Published in 2020 at "Hearing Research"
DOI: 10.1016/j.heares.2020.108019
Abstract: Abstract Hearing and balance deficits have been reported during and following treatment with the antimalarial drug chloroquine. However, experimental work examining the direct actions of chloroquine on mechanoreceptive hair cells in common experimental models is… read more here.
Keywords: lateral line; hair cells; hair; zebrafish lateral ... See more keywords
Early hydroxychloroquine but not chloroquine use reduces ICU admission in COVID-19 patients
Sign Up to like & getrecommendations! Published in 2020 at "International Journal of Infectious Diseases"
DOI: 10.1016/j.ijid.2020.09.1460
Abstract: Background The global push for the use of hydroxychloroquine (HCQ) and chloroquine (CQ) against COVID-19 resulted in an ongoing discussion about the effectivity and toxicity of these drugs. Recent studies report no effect of (H)CQ… read more here.
Keywords: covid patients; use; hcq; effect ... See more keywords
Progressive increase in point mutations associates chloroquine resistance: Even after withdrawal of chloroquine use in India
Sign Up to like & getrecommendations! Published in 2017 at "International Journal for Parasitology: Drugs and Drug Resistance"
DOI: 10.1016/j.ijpddr.2017.06.002
Abstract: Chloroquine (CQ) is highly effective against P. vivax, due to the rapid spread of CQ resistance in P. falciparum parasites; it is no longer the drug of choice against P. falciparum. This study elucidates the… read more here.
Keywords: yysny; chloroquine resistance; resistance; withdrawal chloroquine ... See more keywords
Molecular surveillance of chloroquine-resistant Plasmodium falciparum in sub-Saharan African countries after withdrawal of chloroquine for treatment of uncomplicated malaria: A systematic review.
Sign Up to like & getrecommendations! Published in 2022 at "Journal of infection and public health"
DOI: 10.1016/j.jiph.2022.03.015
Abstract: BACKGROUND A wide spread of chloroquine resistance prompted its discontinued use for treatment of uncomplicated malaria in several African countries. However, disappearances of chloroquine-resistant parasites have been reported in areas with restricted use of chloroquine.… read more here.
Keywords: review; treatment uncomplicated; falciparum; chloroquine resistant ... See more keywords
Chloroquine improves the response to ischemic muscle injury and increases HMGB1 after arterial ligation.
Sign Up to like & getrecommendations! Published in 2018 at "Journal of vascular surgery"
DOI: 10.1016/j.jvs.2017.01.021
Abstract: OBJECTIVE We have previously shown that exogenous administration of the nuclear protein high mobility group box 1 (HMGB1) improves angiogenesis after tissue ischemia. Antagonizing HMGB1 prolongs muscle necrosis and deters regeneration. In this study, we… read more here.
Keywords: hmgb1; muscle; ligation; ischemia ... See more keywords
Neural simulation and experimental investigation of Chloroquine solubility in supercritical solvent
Sign Up to like & getrecommendations! Published in 2021 at "Journal of Molecular Liquids"
DOI: 10.1016/j.molliq.2021.115942
Abstract: Abstract Understanding drug solubility in various solvents is of great importance to the pharmaceutical industry for design of the process. To date, various modeling approaches including Equation of State (EoS) and Semi-empirical correlations have been… read more here.
Keywords: drug solubility; supercritical solvent; neural simulation; solubility ... See more keywords
Dose Optimization of Chloroquine by Pharmacokinetic Modeling During Pregnancy for the Treatment of Zika Virus Infection.
Sign Up to like & getrecommendations! Published in 2019 at "Journal of pharmaceutical sciences"
DOI: 10.1016/j.xphs.2018.10.056
Abstract: The insidious nature of Zika virus (ZIKV) infections can have a devastating consequence for fetal development. Recent reports have highlighted that chloroquine (CQ) is capable of inhibiting ZIKV endocytosis in brain cells. We applied pharmacokinetic… read more here.
Keywords: pharmacokinetic modeling; zika virus; pregnancy; chloroquine ... See more keywords
Chloroquine does not inhibit infection of human lung cells with SARS-CoV-2
Sign Up to like & getrecommendations! Published in 2020 at "Nature"
DOI: 10.1038/s41586-020-2575-3
Abstract: The coronavirus disease 2019 (COVID-19) pandemic, which is caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), has been associated with more than 780,000 deaths worldwide (as of 20 August 2020). To develop antiviral interventions… read more here.
Keywords: lung cells; infection; human lung; chloroquine ... See more keywords