Chloroquine and bafilomycin A mimic lysosomal storage disorders and impair mTORC1 signalling
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DOI: 10.1042/bsr20200905
Abstract: Abstract Autophagy is dependent upon lysosomes, which fuse with the autophagosome to complete the autophagic process and whose acidic interior permits the activity of their intraluminal degradative enzymes. Chloroquine (CQ) and bafilomycin A1 (BafA) each… read more here.
Keywords: chloroquine bafilomycin; lysosomal storage; storage disorders; mtorc1 signalling ... See more keywords