The role of sodium alginate on the supersaturation state of the poorly soluble drug chlorthalidone.
Sign Up to like & getrecommendations! Published in 2019 at "Carbohydrate polymers"
DOI: 10.1016/j.carbpol.2019.01.007
Abstract: Solid dispersions (SDs) of chlorthalidone (CTD) are promising systems to enhance drug dissolution rate, generate and maintain drug supersaturation levels in gastrointestinal fluids. In this work, SDs of CTD were prepared by spray drying using… read more here.
Keywords: drug loading; role sodium; drug; sodium alginate ... See more keywords
Pairwise comparison of hydrochlorothiazide and chlorthalidone responses among hypertensive patients
Sign Up to like & getrecommendations! Published in 2022 at "Clinical and Translational Science"
DOI: 10.1111/cts.13396
Abstract: This study conducted a pairwise comparison of antihypertensive and metabolic effects of hydrochlorothiazide (HCTZ) and chlorthalidone (CTD) at 25 mg/day in the same individuals to address the clinical dilemma on preferred thiazide for hypertension (HTN) management.… read more here.
Keywords: ctd; chlorthalidone; comparison hydrochlorothiazide; reduction ... See more keywords
Superior antihypertensive and cardioprotective effects of chlorthalidone compared with hydrochlorothiazide.
Sign Up to like & getrecommendations! Published in 2021 at "Drugs of today"
DOI: 10.1358/dot.2021.57.4.3266245
Abstract: Diuretics are the most commonly used drugs for the treatment of hypertension, either alone or in combination with other antihypertensive drugs. Of all diuretics, hydrochlorothiazide (HCTZ) and chlorthalidone (CTD) are the most commonly used, with… read more here.
Keywords: cardioprotective effects; effects chlorthalidone; antihypertensive cardioprotective; chlorthalidone compared ... See more keywords
Tailoring Chlorthalidone Aqueous Solubility by Cocrystallization: Stability and Dissolution Behavior of a Novel Chlorthalidone-Caffeine Cocrystal
Sign Up to like & getrecommendations! Published in 2022 at "Pharmaceutics"
DOI: 10.3390/pharmaceutics14020334
Abstract: A cocrystal of the antihypertensive drug chlorthalidone (CTD) with caffeine (CAF) was obtained (CTD-CAF) by the slurry method, for which a 2:1 stoichiometric ratio was found by powder and single-crystal X-ray diffraction analysis. Cocrystal CTD-CAF… read more here.
Keywords: ctd; caf; dissolution; solubility ... See more keywords
In advanced CKD with poorly controlled hypertension, chlorthalidone reduced BP at 12 wk
Sign Up to like & getrecommendations! Published in 2022 at "Annals of Internal Medicine"
DOI: 10.7326/j22-0007
Abstract: SOURCE CITATION Agarwal R, Sinha AD, Cramer AE, et al. Chlorthalidone for hypertension in advanced chronic kidney disease. N Engl J Med. 2021;385:2507-19. 34739197. read more here.
Keywords: advanced ckd; controlled hypertension; poorly controlled; hypertension ... See more keywords
In older adults with hypertension, chlorthalidone vs. hydrochlorothiazide did not reduce major CV events or deaths at 2.4 y
Sign Up to like & getrecommendations! Published in 2023 at "Annals of Internal Medicine"
DOI: 10.7326/j23-0018
Abstract: SOURCE CITATION Diuretic Comparison Project Writing Group; Ishani A, Cushman WC, Leatherman SM, et al. Chlorthalidone vs. hydrochlorothiazide for hypertension-cardiovascular events. N Engl J Med. 2022;387:2401-10. 36516076. read more here.
Keywords: adults hypertension; chlorthalidone; chlorthalidone hydrochlorothiazide; older adults ... See more keywords