SIRT6 Protects Against Myocardial Ischemia–Reperfusion Injury by Attenuating Aging-Related CHMP2B Accumulation
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Cardiovascular Translational Research"
DOI: 10.1007/s12265-021-10184-y
Abstract: Impaired autophagic flux induces aging-related ischemia vulnerability, which is the hallmark pathology in cardiac aging. Our previous work has confirmed that the accumulation of charged multivesicular body protein 2B (CHMP2B), a subunit of the ESCRT-III… read more here.
Keywords: ischemia; accumulation; chmp2b accumulation; aging related ... See more keywords
Frontotemporal dementia causative CHMP2B impairs neuronal endolysosomal traffic-rescue by TMEM106B knockdown
Sign Up to like & getrecommendations! Published in 2018 at "Brain"
DOI: 10.1093/brain/awy284
Abstract: See Bechek and Gitler (doi:10.1093/brain/awy294) for a scientific commentary on this article. Mutations in the endosome-associated protein CHMP2B cause frontotemporal dementia (FTD). Clayton et al. report a mechanism for CHMP2B-mediated neuronal dysfunction and a potential… read more here.
Keywords: frontotemporal dementia; chmp2b; causative chmp2b; dementia causative ... See more keywords