Analysis of differential gene expression and alternative splicing is significantly influenced by choice of reference genome.
Sign Up to like & getrecommendations! Published in 2019 at "RNA"
DOI: 10.1261/rna.070227.118
Abstract: RNA-seq analysis has enabled the evaluation of transcriptional changes in many species including nonmodel organisms. However, in most species only a single reference genome is available and RNA-seq reads from highly divergent varieties are typically… read more here.
Keywords: reference; choice reference; analysis; reference genome ... See more keywords
Impact of the choice of reference genome on the ability of the core genome SNV methodology to distinguish strains of Salmonella enterica serovar Heidelberg
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DOI: 10.1371/journal.pone.0192233
Abstract: Salmonella enterica serovar Heidelberg (S. Heidelberg) is one of the top serovars causing human salmonellosis. The core genome single nucleotide variant pipeline (cgSNV) is one of several whole genome based sequence typing methods used for… read more here.
Keywords: methodology; reference genome; choice reference; genome ... See more keywords