Recent advances in the design of choline kinase α inhibitors and the molecular basis of their inhibition
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DOI: 10.1002/med.21746
Abstract: Upregulated choline metabolism, characterized by an increase in phosphocholine (PCho), is a hallmark of oncogenesis and tumor progression. Choline kinase (ChoK), the enzyme responsible for PCho synthesis, has consequently become a promising drug target for… read more here.
Keywords: chok inhibitors; molecular basis; recent advances; choline kinase ... See more keywords