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   Articles with "chol" as a keyword



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Identification of a New Cholesterol‐Binding Site within the IFN‐γ Receptor that is Required for Signal Transduction

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recommendations! Published in 2022 at "Advanced Science"

DOI: 10.1002/advs.202105170

Abstract: The cytokine interferon‐gamma (IFN‐γ) is a master regulator of innate and adaptive immunity involved in a broad array of human diseases that range from atherosclerosis to cancer. IFN‐γ exerts it signaling action by binding to… read more here.

Keywords: chol; signal transduction; cholesterol; receptor ... See more keywords
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Optimization of liposomal topotecan for use in treating neuroblastoma

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recommendations! Published in 2017 at "Cancer Medicine"

DOI: 10.1002/cam4.1083

Abstract: The purpose of this work was to develop an optimized liposomal formulation of topotecan for use in the treatment of patients with neuroblastoma. Drug exposure time studies were used to determine that topotecan (Hycamtin) exhibited… read more here.

Keywords: topotecan use; formulation; drug; liposomal topotecan ... See more keywords
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Freestanding Helical Nanostructured Chiro-Photonic Crystal Film and Anticounterfeiting Label Enabled by a Cholesterol-Grafted Light-Driven Molecular Motor.

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recommendations! Published in 2022 at "Small methods"

DOI: 10.1002/smtd.202200269

Abstract: Design and fabrication of freestanding chiro-photonic crystal film with the ability to change color over the whole visible light spectrum is appealing for anticounterfeiting technology and smart labels. Utilizing a newly synthesized light-responsive molecular motor… read more here.

Keywords: crystal; chiro photonic; crystal film; cholesterol ... See more keywords
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Phase behavior of cholesterol-containing binary membrane of an ether-linked phospholipid, dihexadecylphosphatidylcholine

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recommendations! Published in 2018 at "Colloid and Polymer Science"

DOI: 10.1007/s00396-018-4280-4

Abstract: The thermotropic phase behavior of the cholesterol (Chol)-containing binary membrane of dihexadecylphosphatidylcholine (DHPC) was investigated as a function of the mole fraction of Chol Xch by DSC and fluorescence spectroscopy using 6-propionyl-2-(N,N-dimethylamino)naphthalene (Prodan). The main-transition… read more here.

Keywords: phase; xch; binary membrane; chol ... See more keywords
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Effects of cholesterol on chlorzoxazone translocation across POPC bilayer

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recommendations! Published in 2021 at "Journal of Molecular Modeling"

DOI: 10.1007/s00894-021-04777-2

Abstract: Cholesterol plays a crucial role in modulating the physicochemical properties of membranes, thus influencing the membrane transport of drugs. In this paper, the effects caused by cholesterol on the membrane transport of chlorzoxazone (CZX), a… read more here.

Keywords: czx permeation; translocation across; chlorzoxazone; concentration ... See more keywords
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Mitochondrion- and nucleus-acting polymeric nanoagents for chemo-photothermal combination therapy

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recommendations! Published in 2020 at "Science China Materials"

DOI: 10.1007/s40843-019-1260-y

Abstract: Developing intrinsically mitochondria-targetable nanosystems for subcellular structure-oriented precise cancer therapy is highly desirable. Here, we conjugate the cluster determinant 44 (CD44)-targetable hyaluronic acid (HA) with cholesterol-poly(ethylene glycol) 2k -NH 2 and mitochondria-acting IR825-NH 2 (a… read more here.

Keywords: chol; hcpt; chemo photothermal; therapy ... See more keywords
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Dynamics of sphingomyelin- and cholesterol-enriched lipid domains during cytokinesis.

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recommendations! Published in 2017 at "Methods in cell biology"

DOI: 10.1016/bs.mcb.2016.03.030

Abstract: Sphingomyelin (SM) and cholesterol (Chol) are the major lipids in the mammalian cells, which are mainly localized to the plasma membrane. Multiple lines of evidence suggest that these lipids form local lipid domains in the… read more here.

Keywords: chol; lipid domains; sphingomyelin cholesterol; domains cytokinesis ... See more keywords
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Induced packaging of mRNA into polyplex micelles by regulated hybridization with a small number of cholesteryl RNA oligonucleotides directed enhanced in vivo transfection.

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recommendations! Published in 2019 at "Biomaterials"

DOI: 10.1016/j.biomaterials.2019.01.023

Abstract: There has been a progressive interest in the molecular design of polymers and lipids as synthetic carriers for targeting therapeutic mRNA in vivo with the ability to circumvent nuclease attack for treating intractable diseases. Herein,… read more here.

Keywords: rna oligonucleotides; chol oligorna; polyplex micelles; cholesteryl ... See more keywords
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Changes in Cholesterol Level Alter Integrin Sequestration in Raft-Mimicking Lipid Mixtures.

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recommendations! Published in 2018 at "Biophysical journal"

DOI: 10.1016/j.bpj.2017.11.005

Abstract: The influence of cholesterol (CHOL) level on integrin sequestration in raft-mimicking lipid mixtures forming coexisting liquid-ordered (lo) and liquid-disordered (ld) lipid domains is investigated using complementary, single-molecule-sensitive, confocal detection methods. Systematic analysis of membrane protein… read more here.

Keywords: sequestration; sequestration raft; level; membrane ... See more keywords
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Complexation of Chol‐DsiRNA in place of Chol‐siRNA greatly increases the duration of mRNA suppression by polyplexes of PLL(30)‐PEG(5K) in primary murine syngeneic breast tumors after i.v. administration

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recommendations! Published in 2018 at "International Journal of Pharmaceutics"

DOI: 10.1016/j.ijpharm.2018.03.045

Abstract: &NA; RNA interference has tremendous potential for cancer therapy but is limited by the insufficient potency of RNAi molecules after i.v. administration. We previously found that complexation with PLL(30)‐PEG(5K) greatly increases the potency of 3′‐cholesterol‐modified… read more here.

Keywords: suppression; chol dsirna; chol sirna; pll peg ... See more keywords
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Freeze-drying cycle optimization for the rapid preservation of protein- loaded liposomal formulations.

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recommendations! Published in 2019 at "International journal of pharmaceutics"

DOI: 10.1016/j.ijpharm.2019.118722

Abstract: Technology such as the use of microfluidics to generate liposomes has been well researched, yet the stabilisation of liposomal formulations is a major challenge to their greater implementation. To the best of our knowledge, this… read more here.

Keywords: protein; freeze drying; drying cycle; liposomal formulations ... See more keywords