Identification of a New Cholesterol‐Binding Site within the IFN‐γ Receptor that is Required for Signal Transduction
Sign Up to like & getrecommendations! Published in 2022 at "Advanced Science"
DOI: 10.1002/advs.202105170
Abstract: The cytokine interferon‐gamma (IFN‐γ) is a master regulator of innate and adaptive immunity involved in a broad array of human diseases that range from atherosclerosis to cancer. IFN‐γ exerts it signaling action by binding to… read more here.
Keywords: chol; signal transduction; cholesterol; receptor ... See more keywords
Optimization of liposomal topotecan for use in treating neuroblastoma
Sign Up to like & getrecommendations! Published in 2017 at "Cancer Medicine"
DOI: 10.1002/cam4.1083
Abstract: The purpose of this work was to develop an optimized liposomal formulation of topotecan for use in the treatment of patients with neuroblastoma. Drug exposure time studies were used to determine that topotecan (Hycamtin) exhibited… read more here.
Keywords: topotecan use; formulation; drug; liposomal topotecan ... See more keywords
Surface charge, but not size, of liposomes is involved in the suppression of rat basophilic leukemia (RBL‐2H3) cell degranulation mediated by Akt phosphorylation
Sign Up to like & getrecommendations! Published in 2024 at "Cell Biology International"
DOI: 10.1002/cbin.12205
Abstract: Cationic liposomes composed of cholesteryl‐3β‐carboxyamidoethylene‐N‐hydroxyethylamine (OH‐chol) and 1,2‐dioleoyl‐sn‐glycero‐3‐phosphatidylethanolamine (DOPE) inhibit mast cell degranulation mediated via crosslinking of high‐affinity IgE receptors (FcεRI). Although the inhibitory efficiency of mast cell degranulation is altered by modifying the ratio… read more here.
Keywords: ratio chol; phosphorylation; chol; cell ... See more keywords
Freestanding Helical Nanostructured Chiro-Photonic Crystal Film and Anticounterfeiting Label Enabled by a Cholesterol-Grafted Light-Driven Molecular Motor.
Sign Up to like & getrecommendations! Published in 2022 at "Small methods"
DOI: 10.1002/smtd.202200269
Abstract: Design and fabrication of freestanding chiro-photonic crystal film with the ability to change color over the whole visible light spectrum is appealing for anticounterfeiting technology and smart labels. Utilizing a newly synthesized light-responsive molecular motor… read more here.
Keywords: crystal; chiro photonic; crystal film; cholesterol ... See more keywords
Phase behavior of cholesterol-containing binary membrane of an ether-linked phospholipid, dihexadecylphosphatidylcholine
Sign Up to like & getrecommendations! Published in 2018 at "Colloid and Polymer Science"
DOI: 10.1007/s00396-018-4280-4
Abstract: The thermotropic phase behavior of the cholesterol (Chol)-containing binary membrane of dihexadecylphosphatidylcholine (DHPC) was investigated as a function of the mole fraction of Chol Xch by DSC and fluorescence spectroscopy using 6-propionyl-2-(N,N-dimethylamino)naphthalene (Prodan). The main-transition… read more here.
Keywords: phase; xch; binary membrane; chol ... See more keywords
Downregulation of dermatopontin in cholangiocarcinoma cells suppresses CCL19 secretion of macrophages and immune infiltration
Sign Up to like & getrecommendations! Published in 2024 at "Journal of Cancer Research and Clinical Oncology"
DOI: 10.1007/s00432-023-05532-1
Abstract: Objective The tumor microenvironment (TME) in cholangiocarcinoma (CHOL) is typically characterized by a low level of immune infiltration, which accounts for the dismal prognosis of this patient population. This study sought to investigate the mechanisms… read more here.
Keywords: immune infiltration; ccl19 secretion; dpt; chol ... See more keywords
Effects of cholesterol on chlorzoxazone translocation across POPC bilayer
Sign Up to like & getrecommendations! Published in 2021 at "Journal of Molecular Modeling"
DOI: 10.1007/s00894-021-04777-2
Abstract: Cholesterol plays a crucial role in modulating the physicochemical properties of membranes, thus influencing the membrane transport of drugs. In this paper, the effects caused by cholesterol on the membrane transport of chlorzoxazone (CZX), a… read more here.
Keywords: czx permeation; translocation across; chlorzoxazone; concentration ... See more keywords
Mitochondrion- and nucleus-acting polymeric nanoagents for chemo-photothermal combination therapy
Sign Up to like & getrecommendations! Published in 2020 at "Science China Materials"
DOI: 10.1007/s40843-019-1260-y
Abstract: Developing intrinsically mitochondria-targetable nanosystems for subcellular structure-oriented precise cancer therapy is highly desirable. Here, we conjugate the cluster determinant 44 (CD44)-targetable hyaluronic acid (HA) with cholesterol-poly(ethylene glycol) 2k -NH 2 and mitochondria-acting IR825-NH 2 (a… read more here.
Keywords: chol; hcpt; chemo photothermal; therapy ... See more keywords
Dynamics of sphingomyelin- and cholesterol-enriched lipid domains during cytokinesis.
Sign Up to like & getrecommendations! Published in 2017 at "Methods in cell biology"
DOI: 10.1016/bs.mcb.2016.03.030
Abstract: Sphingomyelin (SM) and cholesterol (Chol) are the major lipids in the mammalian cells, which are mainly localized to the plasma membrane. Multiple lines of evidence suggest that these lipids form local lipid domains in the… read more here.
Keywords: chol; lipid domains; sphingomyelin cholesterol; domains cytokinesis ... See more keywords
Induced packaging of mRNA into polyplex micelles by regulated hybridization with a small number of cholesteryl RNA oligonucleotides directed enhanced in vivo transfection.
Sign Up to like & getrecommendations! Published in 2019 at "Biomaterials"
DOI: 10.1016/j.biomaterials.2019.01.023
Abstract: There has been a progressive interest in the molecular design of polymers and lipids as synthetic carriers for targeting therapeutic mRNA in vivo with the ability to circumvent nuclease attack for treating intractable diseases. Herein,… read more here.
Keywords: rna oligonucleotides; chol oligorna; polyplex micelles; cholesteryl ... See more keywords
Changes in Cholesterol Level Alter Integrin Sequestration in Raft-Mimicking Lipid Mixtures.
Sign Up to like & getrecommendations! Published in 2018 at "Biophysical journal"
DOI: 10.1016/j.bpj.2017.11.005
Abstract: The influence of cholesterol (CHOL) level on integrin sequestration in raft-mimicking lipid mixtures forming coexisting liquid-ordered (lo) and liquid-disordered (ld) lipid domains is investigated using complementary, single-molecule-sensitive, confocal detection methods. Systematic analysis of membrane protein… read more here.
Keywords: sequestration; sequestration raft; level; membrane ... See more keywords